Script modules

Question 1

What is oxybutynin?

Answer 1

antimuscarinic drug used to relax an overactive bladder

Question 2

SEs of oxybutynin?

Answer 2

dry mouth, constipation, blurred vision and occasionally cognitive impairment

Question 3

SEs of statins?

Answer 3

Headaches + GI disturbances

More serious: muscle aches -> myopathy

Question 4

Name a SE of systemic steroids (pred)

Answer 4

Mood changes

An onset of such symptoms during treatment will require a review of therapy

Question 5

Which abx reacts with Warfarin?

Answer 5

Erythromycin - enhances anticoagulation effects

Question 6

Which abx reacts with ferrous sulphate?

Answer 6

Fluoroquinolones - ciprofloxacin (absorption reduced by oral iron)

Question 7

Which drugs cause what reaction in patients with G6PD deficiency?

Answer 7

Haemolytic anaemia
Antimalarials
Nitrofurantoin
Quinolone abx etc

Question 8

What can happen to afro-caribbean patients who take ACE-i?

Answer 8

Angiooedema

Question 9

What is the ADR with Methotrexate?

Answer 9

Blood dyscrasia

Question 10

What ADR occurs when vancomycin is given too rapidly?

Answer 10

Red man syndrome

Question 11

What oral antifungal interacts with warfarin?

Answer 11

Miconazole

Question 12

Which drug is less effective in some Asian populations?

Answer 12

Clopidogrel - these populations exhibit poorer expression of the enzymes that activate the drug

Question 13

What can happen if you give sildenafil and glyceryl trinitrate together?

Answer 13

Severe hypotension and potential MI

Question 14

Which foods may have a bearing on Warfarins effect?

Answer 14

Vit K foods - green leafy veg

Question 15

How do rifampicin and cOCP interact?

Answer 15

Rifampicin induces CYP450
This causes activation of drug metabolising enzymes
Reduces the effect of hormones
Reduces effectiveness of OCP

Question 16

What do macrolides do to warfarin?

Answer 16

Interact and cause a rise in INR

Question 17

Which drugs can cause otoxicity?

Answer 17

Aminoglycosides (gentamicin), loop diuretics

Question 18

Which drugs can inhibit the ‘efflux’ protein P-glycoprotein?

Answer 18

Verapamil, atorvastatin, amiodarone

Question 19

What affect does garlic have on the blood?

Answer 19

Inhibits platelet aggregation

Question 20

What can ginseng interact with (causing hypoglycaemia)?

Answer 20

Gliclazides

Question 21

What can St. John’s Wort interact with?

Answer 21

Antidepressants - can increase the risk of serotonin syndrome and hypertensive crisis when prescribed with MAOs

Question 22

What can liquorice do to drugs?

Answer 22

Cause hypokalaemia and increase the risk of digoxin toxicity

Question 23

What should you monitor prior to treatment with adalimumab?

Answer 23

Check for TB infection

Question 24

How often do you check INR for LMWHs?

Answer 24

You don’t need to