Script modules Flashcards
What is oxybutynin?
antimuscarinic drug used to relax an overactive bladder
SEs of oxybutynin?
dry mouth, constipation, blurred vision and occasionally cognitive impairment
SEs of statins?
Headaches + GI disturbances
More serious: muscle aches -> myopathy
Name a SE of systemic steroids (pred)
Mood changes
An onset of such symptoms during treatment will require a review of therapy
Which abx reacts with Warfarin?
Erythromycin - enhances anticoagulation effects
Which abx reacts with ferrous sulphate?
Fluoroquinolones - ciprofloxacin (absorption reduced by oral iron)
Which drugs cause what reaction in patients with G6PD deficiency?
Haemolytic anaemia
Antimalarials
Nitrofurantoin
Quinolone abx etc
What can happen to afro-caribbean patients who take ACE-i?
Angiooedema
What is the ADR with Methotrexate?
Blood dyscrasia
What ADR occurs when vancomycin is given too rapidly?
Red man syndrome
What oral antifungal interacts with warfarin?
Miconazole
Which drug is less effective in some Asian populations?
Clopidogrel - these populations exhibit poorer expression of the enzymes that activate the drug
What can happen if you give sildenafil and glyceryl trinitrate together?
Severe hypotension and potential MI
Which foods may have a bearing on Warfarins effect?
Vit K foods - green leafy veg
How do rifampicin and cOCP interact?
Rifampicin induces CYP450
This causes activation of drug metabolising enzymes
Reduces the effect of hormones
Reduces effectiveness of OCP
What do macrolides do to warfarin?
Interact and cause a rise in INR
Which drugs can cause otoxicity?
Aminoglycosides (gentamicin), loop diuretics
Which drugs can inhibit the ‘efflux’ protein P-glycoprotein?
Verapamil, atorvastatin, amiodarone
What affect does garlic have on the blood?
Inhibits platelet aggregation
What can ginseng interact with (causing hypoglycaemia)?
Gliclazides
What can St. John’s Wort interact with?
Antidepressants - can increase the risk of serotonin syndrome and hypertensive crisis when prescribed with MAOs
What can liquorice do to drugs?
Cause hypokalaemia and increase the risk of digoxin toxicity
What should you monitor prior to treatment with adalimumab?
Check for TB infection
How often do you check INR for LMWHs?
You don’t need to
