Schizophrenia: Exam 2 Flashcards
What are the major behaviors regarding Schizophrenia?
perceptions
thought (cognitive): process and content
affect (emotions)
motivation
What a person feels is not in keeping with what one would normally expect.
What major behavior is this?
Affect (emotions)
What does the major behavior: affect (emotions) consist of?
Blunted
Flattened
Inappropriate
Over-responsive
Labile
What does the major behavior: motivation consist of?
Withdrawal
Regression
Ambivalence
Changes in motor behavior: catatonic, motor excitement, and impulsive behavior.
What are the positive symptoms of schizophrenia?
- Delusions
- Bizarre Behavior
- Paranoia
- Hallucinations
- Disorganized
Speech - Mutism
What are the negative symptoms of schizophrenia?
- Flat Affect
- Inappropriate Affect
- Poverty of Thought
- Lack of Energy
- Emotional
Ambivalence - Inability to
Experience Pleasure
The onset of schizophrenia may be ______ or ________. Most clients slowley and gradually develop signs and symptoms.
Abrupt
Gradual
________ usually with more actively positive symptoms of psychosis. Regardless of when and how the illness begins and the type of ___________, consequences for most clients and their families are substantial and enduring.
Diagnosis
Schizophrenia
______ and how the illness develops seems to affect the _______. Age at onset appears to be an important factor in how _____ the client fares.
When
Outcome
Well
What do younger clients display?
Poorer premorbid adjustment
More prominent negative signs
Greater cognitive impairment
Those who experience ______ onset (about 50%) tend to have a _______ immediate and long-term course than those who experience an _____ and sudden onset.
Gradual
Poorer
Acute
Approximately 1/3 to ½ of clients with schizophrenia relapse within 1 year of an acute episode.
Higher relapse rates are associated with:
Medication noncompliance
Substance use
Caregiver criticism (stigma)
Negative attitude toward treatment
What are the 2 patterns of immediate-term course?
Ongoing psychosis (the person never fully recovers)
Episodes of psychotic symptoms alternating with episodes of relatively complete recovery
What is included in the long-term course?
Intensity of psychosis diminishes with age
Disease becomes less disruptive
Clients may live independently later in life
Many have difficulty functioning in the community
What are the related disorders to schizophrenia?
Schizophreniform
Catatonia
Delusional
Brief psychotic
Shared psychotic
Schizotypal personality
Neurological-anatomical:
Brain structure and functioning
-Changes in basal ganglia activity
-Structural brain abnormalities: what does the abnormalities include?
Cerebral atrophy
Decreased cerebral blood flow
Decreased brain volume
Findings have demonstrated that people with schizophrenia have relatively less brain tissue and cerebrospinal fluid than those who do not have schizophrenia
Brain structure and functioning
Reduced _______ metabolism in the frontal and temporal lobes as seen on imaging studies (CT, MRI, and PET scan).
Imbalance between _________ systems (dopamine, serotonin, PCP glutamate, norepinephrine, gamma-aminobutyric acid, and acetylcholine [GABA]).
Glucose
Neurotransmitter
What do the genetic factors include in regards to neurological-anatomical?
Increased risk for schizophrenia associated with a positive family history of schizophrenia
Increased risk for schizophrenia with first-degree relatives diagnosed with schizophrenia
No specific genetic defect identified that causes schizophrenia
Recent studies indicate that the genetic risk of schizophrenia is polygenic, meaning several genes contribute to the development (Kendler, 2015).
Genetic Factors
Intrauterine influences such as poor nutrition, tobacco, alcohol, and other drugs, and stress also are being studied as possible causes of the brain pathology found in people with schizophrenia (Sadock et al., 2015)
Environmental Factors
Viral exposure or the body’s immune response to a virus could alter the brain pathology of people with schizophrenia
Cytokines
Infections in pregnant women
Immunovirological factors
chemical messengers between immune cells that mediate inflammatory and immune responses
Cytokines
Specific cytokines play a role in signaling the brain to produce behavioral and neurochemical changes needed.
Describe the infections in pregnant women.
Higher rates of schizophrenia among children born in crowded areas in cold weather or conditions that are hospitable to respiratory ailments
1st discovered—Thorazine — have more effect on positive symptoms
Anti-psychotics (Neuroleptics) Typical
newer — effective in treating both positive and negative symptoms — fewer extrapyramidal side effects
Anti-psychotics (Neuroleptics) Atypical
Overview for Anti-psychotics (Neuroleptics):
Do not cure—control symptoms
Reduce anxiety
Decrease hallucinations and delusions
Increase ability to respond to other forms of treatment.
Atypical—decrease negative symptoms
What are the pharmacokinetics regarding anti-psychotics (Neuroleptics)?
Well absorbed by GI tract
Metabolized by liver
Food & antacids can ↓ absorbtion
½ life 18-20 hrs except deconates
Passed onto fetus & in breast milk
Rapid sedative effect—takes longer to get antipsychotic effect
Neuroleptics Typical (1st Gen.)
Thorazine
Chlorpromazine
Haldol
Haloperidol
Prolixin
Fluphenazine
Loxitane
Loxapine
Trilafon
Perphenazine
Mellaril
Thioridazine
Neuroleptics Atypical (2nd Gen.)
Clozaril
Clozapine
Risperdal
Respiridone
Zyprexa
Olanzapine
Geodon
Ziprasidone
Abilify
Aripiprazole
Invega
Paliperidone