Schizophrenia Drug Therapy: Typical and Atypical antipsychotics Flashcards
What is an example of a typical antipsychotic?
Chlorpromazine
Are typical antipsychotics an antagonist or an agonist?
Antagonist
What kind of antagonist are typical antipsychotics?
Dopamine Antagonist
How does Chlorpromazine work?
Binds to the D2 receptors
Where are the D2 receptors?
On the post synoptic neurons in the brain
What does Chlorpromazine do?
Reduces the dopamine activity levels
What does a reduction in dopamine activity levels lead to?
A reduction in postive symptoms such as hallucinations
What are Typical Antipsychotics also used for?
A sedative
Calming patients
What is an example of Atypical Antipsychotic?
Clozapine
Is Clozapine an antagonist or an antagonist?
Both
What does Clozapine act upon?
Dopamine and serotonin neurotransmitter
What does Clozapine bind to?
D2 dopamine receptor sites on post synoptic neuron
What does Clozapine reduce?
Positive symptoms such as hallucinations
What does Clozapine also act upon?
Serotonin receptor sites (2A and 2C)
Why does Clozapine act upon serotonin?
To increase levels of serotonin