Addiction: Reducing Addiction - Drug Therapy Flashcards
What is the drug therapy for nicotine addiction?
Nicotine replacement therapy
What is NRT?
A agonist substitution
What does NRT do?
Increases neurotransmitter activity
What is the aim of NRT?
Provide nicotine from a less harmful source
1 - How does NRT work?
Stimulates the nicotine receptors and activates the brain’s reward pathway
Releases dopamine into the limbic system
Stimulates the nucleus accumbens, creates pleasureable feeling
1 - What does NRT lead to?
A reduction in nicotine withdrawal symptoms
Stops cravings
1 - What is the withdrawal symptom an example of?
Negative reinforcements as the NRT removes the unpleasant circumstances of quitting smoking
2 - What does NRT also do?
Desensitises the nicotine receptors in the brain by releasing small amounts of nicotine so that ony some receptors are full with nicotine, not all
2 - Over time what happens to the nicotine receptors?
Reduce which means the cigarettes become less rewarding to smoke
Relapse is less likely
Gradually reduce the dosage of nicotine as thei tolerance to nicotine is reduced as the tolerance is reduced
What is the drug therapy for gambling addiction?
Opioid Antagonist
What does the opioid antagonist do?
Reduce neurotransmitter activity
What is the aim of opioid antagonist?
Reduce the pleasureable feeling associated with gambling
How does the opioid antagonist work?
Enhances the release of neurotransmittrers GABA in the mesolimbic pathway
What deos the increased GABA activity ?
Reduces the release of dopamine in the nucleus accumbens
Linked with reductions in gambling behaviour
1 - Who researched the effectiveness of NRT?
Stead et al