Schizophrenia and Depression

Question 1

What are the positive symptoms of schizophrenia?

Answer 1

1. Delusions

2. Hallucinations

Question 2

What are the negative symptoms of schizophrenia?

Answer 2

1. Avolition (lack of motivation)
2. Alogia (poverty of speech)
3. Anhedonia (inability to experience pleasure)
4. Affective flattening (exhibits little or no affect in face or voice)
5. Asociality (inability to form close personal relationship)

Question 3

What are the disorganised symptoms of schizophrenia?

Answer 3

1. Disorganised speech (formal thought disorder)
2. Incoherence
3. Loose associations
4. Disorganised behaviour
5. Silliness, agitation, unusual dress

Question 4

What are the other symptoms of schizophrenia?

Answer 4

1. Catatonia - repetitive complex gestures
2. Catatonic immobility
3. Waxy flexibility
4. Inappropriate affect

Question 5

What are Liddle’s three syndromes in schizophrenia?

Answer 5

1. Reality distortion syndrome
2. Psychomotor poverty syndrome
3. Disorganisation syndrome

Question 6

What brain activity is associated with reality distortion syndrome?

Answer 6

Overactivity in left parahippocampal region and left striatum

Question 7

What brain activity is associated with psychomotor poverty syndrome?

Answer 7

Hypoperfusion of left dorsal, medial prefrontal cortex, cingulate cortex and head of caudate

Question 8

What brain activity is associated with disorganisation syndrome?

Answer 8

1. Hypoperfusion of R ventral perfrontal cortex, increased activity in ant. cingulate & dorsolateral thalamic nuclei projecting to prefrontal cortex
2. Hypoperfusion of Broca’s area & parietal association cortex

Question 9

Which symptoms are part of the ICD criteria for schizophrenia?

Answer 9

1. Thought echo
2. Delusions of control
3. Hallucinatory voices
4. Persistent delusions