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NHB > CNS Pharmacology Drugs > Flashcards

CNS Pharmacology Drugs Flashcards

1
Q

Kainate

A

AMPA receptor agonist

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2
Q

Domoate

A

AMPA receptor agonist

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3
Q

Memantine

A

NMDA receptor open channel blocker

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4
Q

Ketamine

A

NMDA receptor antagonist

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5
Q

Dizolcipine

A

NMDAR antagonist

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6
Q

Alteplase

A

Thrombolytic

Recombinant tissue plasminogen activator

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7
Q

Aptiganel

A

Glutamate receptor antagonist

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8
Q

Nicardipine

A

Calcium channel blocker

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9
Q

Lamotrigine

A

Sodium channel blocker

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10
Q

Vigabatrin

A

Blockade of GABA transaminase

Prevents GABA breakdown in presynaptic terminal

Used in epilepsy

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11
Q

Valproate

A

Sodium channel blocker

Inhibition of succinate semialdehyde dehydrogenase (SSADH)

Reduces presynaptic degradation of GABA

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12
Q

Tiagabine

A

Prolongs action of GABA in synaptic cleft

Selective GAT-1 inhibitor

Anticonvulsant

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13
Q

Baclofen

A

GABAB agonist

Antispasmodic

Treatment of alcohol addiction

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14
Q

Muscimol

A

GABAA-receptor agonist

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15
Q

Bicuculline

A

Competitive GABAA receptor antagonist

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16
Q

Picrotoxin

A

Blocks ion channel of GABAA

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17
Q

Benzodiazepine

A

Allosteric modulator of GABA receptor

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18
Q

Barbiturates

A

Allosteric modulator of GABA receptor

Enhancement

Stops spread of seizures

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19
Q

Alcohol

A

Allosteric modulator of GABA receptor

20
Q

Phenytoin

A

Sodium channel blocker

21
Q

Gabapentin

A

Inhibition of L-type calcium channels

Antiepileptic

Effective for absence seizures

22
Q

Ethosuximide

A

Inhibits T-type calcium channels

23
Q

Trimethadione

A

Inhibits T-type calcium channels

24
Q

Propranolol

A

Non-selective beta adrenoceptor blocker

Treatment of somatic anxiety

25
Q

Zolpidem

A

Binds to benzodiazepine binding site (though not a benzodiazepine)

Used for insomnia

26
Q

Iproniazid

A

MAO inhibitor

27
Q

Moclobemide

A

Reversible MAO inhibitor

Specific for MAO-A

28
Q

Imipramine

A

Tricyclic antidepressant

Acts on NET transporter

29
Q

Venlaxafine

A

Serotonin and noradrenaline reuptake inhibitor

30
Q

Bupropion

A

Atypical antidepressant

Acts via DAT

31
Q

Agomelatine

A

Antagonist activity at 5HT2C receptors

Agonist activity at melatonergic MT1/MT2 receptors

32
Q

Reserpine

A

Depletes catecholamines by inhibiting vesicular uptake

33
Q

Amphetamine

A

Releases catecholamines

34
Q

Cocaine

A

Inhibits catecholamine reuptake

Blocks NET

35
Q

Apomorphine

A

DA receptor agonist

36
Q

SCH 23390

A

Blocks D1 receptors

37
Q

Haloperidol

A

Blocks D2 receptors

Typical antipsychotic

38
Q

Selegiline

A

Inhibits MAO-B

39
Q

Entacapone

A

Inhibits COMT

40
Q

Methylphenidate (ritalin)

A

Increases dopamine’s action at synapses

41
Q

Chlorpromazine

A

Antihistamine

Typical antipsychotic

42
Q

Clozapine

A

Atypical antipsychotic

D2 antagonist

5HT2A antagonist

43
Q

Carbidopa

A

Peripheral DDC inhibitor

44
Q

Domperidone

A

D2 antagonist that does not cross the blood brain barrier

Used to treat nausea

45
Q

Bromocriptine

A

Potent D2 receptor agonist

46
Q

Donepezil

A

Short-acting cholinesterase inhibitor

NHB (17 decks)

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