CNS Pharmacology Drugs

Question 1

Kainate

Answer 1

AMPA receptor agonist

Question 2

Domoate

Answer 2

AMPA receptor agonist

Question 3

Memantine

Answer 3

NMDA receptor open channel blocker

Question 4

Ketamine

Answer 4

NMDA receptor antagonist

Question 5

Dizolcipine

Answer 5

NMDAR antagonist

Question 6

Alteplase

Answer 6

Thrombolytic

Recombinant tissue plasminogen activator

Question 7

Aptiganel

Answer 7

Glutamate receptor antagonist

Question 8

Nicardipine

Answer 8

Calcium channel blocker

Question 9

Lamotrigine

Answer 9

Sodium channel blocker

Question 10

Vigabatrin

Answer 10

Blockade of GABA transaminase

Prevents GABA breakdown in presynaptic terminal

Used in epilepsy

Question 11

Valproate

Answer 11

Sodium channel blocker

Inhibition of succinate semialdehyde dehydrogenase (SSADH)

Reduces presynaptic degradation of GABA

Question 12

Tiagabine

Answer 12

Prolongs action of GABA in synaptic cleft

Selective GAT-1 inhibitor

Anticonvulsant

Question 13

Baclofen

Answer 13

GABAB agonist

Antispasmodic

Treatment of alcohol addiction

Question 14

Muscimol

Answer 14

GABAA-receptor agonist

Question 15

Bicuculline

Answer 15

Competitive GABAA receptor antagonist

Question 16

Picrotoxin

Answer 16

Blocks ion channel of GABAA

Question 17

Benzodiazepine

Answer 17

Allosteric modulator of GABA receptor

Question 18

Barbiturates

Answer 18

Allosteric modulator of GABA receptor

Enhancement

Stops spread of seizures

Question 19

Alcohol

Answer 19

Allosteric modulator of GABA receptor

Question 20

Phenytoin

Answer 20

Sodium channel blocker

Question 21

Gabapentin

Answer 21

Inhibition of L-type calcium channels

Antiepileptic

Effective for absence seizures

Question 22

Ethosuximide

Answer 22

Inhibits T-type calcium channels

Question 23

Trimethadione

Answer 23

Inhibits T-type calcium channels

Question 24

Propranolol

Answer 24

Non-selective beta adrenoceptor blocker

Treatment of somatic anxiety

Question 25

Zolpidem

Answer 25

Binds to benzodiazepine binding site (though not a benzodiazepine) Used for insomnia

Question 26

Iproniazid

Answer 26

MAO inhibitor

Question 27

Moclobemide

Answer 27

Reversible MAO inhibitor Specific for MAO-A

Question 28

Imipramine

Answer 28

Tricyclic antidepressant Acts on NET transporter

Question 29

Venlaxafine

Answer 29

Serotonin and noradrenaline reuptake inhibitor

Question 30

Bupropion

Answer 30

Atypical antidepressant Acts via DAT

Question 31

Agomelatine

Answer 31

Antagonist activity at 5HT2C receptors Agonist activity at melatonergic MT1/MT2 receptors

Question 32

Reserpine

Answer 32

Depletes catecholamines by inhibiting vesicular uptake

Question 33

Amphetamine

Answer 33

Releases catecholamines

Question 34

Cocaine

Answer 34

Inhibits catecholamine reuptake Blocks NET

Question 35

Apomorphine

Answer 35

DA receptor agonist

Question 36

SCH 23390

Answer 36

Blocks D1 receptors

Question 37

Haloperidol

Answer 37

Blocks D2 receptors Typical antipsychotic

Question 38

Selegiline

Answer 38

Inhibits MAO-B

Question 39

Entacapone

Answer 39

Inhibits COMT

Question 40

Methylphenidate (ritalin)

Answer 40

Increases dopamine's action at synapses

Question 41

Chlorpromazine

Answer 41

Antihistamine Typical antipsychotic

Question 42

Clozapine

Answer 42

Atypical antipsychotic D2 antagonist 5HT2A antagonist

Question 43

Carbidopa

Answer 43

Peripheral DDC inhibitor

Question 44

Domperidone

Answer 44

D2 antagonist that does not cross the blood brain barrier Used to treat nausea

Question 45

Bromocriptine

Answer 45

Potent D2 receptor agonist

Question 46

Donepezil

Answer 46

Short-acting cholinesterase inhibitor