Schizophrenia

Question 1

positive symptoms ?

Answer 1

auditory hallucinations

• 3rd person
• running commentary

delusional perception

thought disorder
- thought broadcasting, echo, insertion

passivity phenomena
- bodily sensations being controlled by external influence

Question 2

negative symptoms ?

Answer 2

apathy 
anhedonia
avolition (lack of motivation)
alogia (lack of speech) 
blunting of affect

Question 3

other features of schizophrenia that aren’t part of the positive and negative symptoms ?

Answer 3

lack of insight

incongruity of affect (inappropriate emotion for circumstance)

Question 4

1st line treatment for schizophrenia ?

Answer 4

atypical antipsychotic i.e. olanzapine, quetiapine, risperidone

Question 5

treatment for refractory schizophrenia ?

Answer 5

clozapine (atypical antipsychotic)

Question 6

poor prognostic factors for schizophrenia ?

Answer 6

gradual onset 
low IQ 
lack of obvious precipitant 
strong family history 
prodromal phase of social withdrawal

Question 7

side effects of clozapine ?

Answer 7

agranulocytosis 
leukocytosis 
constipation 
myocarditis 
hyper salivation 
reduced seizure threshold

Question 8

side effects of atypical antipsychotics ?

Answer 8

hyperlipidaemia
sedation 
weight gain 
hyperprolactinaemia 
increased risk of VTE and stroke

Question 9

ICD diagnostic criteria for schizophrenia ?

Answer 9

present for at least one month -

1 of the following;

• auditory hallucinations
• passivity phenomena
• delusional perception
• thought disorder

and/or 2 of the following;

• persistent hallucinations
• neologisms, breaks in train of though resulting in incoherent or irrelevant speech
• negative symptoms
• catatonic behaviour