Schizophrenia

Question 1

Anti-psychotic 1st generation (typical)

Haloperidol, chlorpromazine, prochlorperazine

Common indications

Answer 1

1. Urgent treatment of severe psychomotor agitiation that is causing dangerous or violent behaviour, or to calm patients to permit assessment
2. Schizophrenia- particularly when the metabolic side effects of 2nd-gen (Atypical) anti-psychotics are likely to be problematic
3. Bipolar disorder- particularly in acute episodes of mania or hypomania
4. N&V- particularly in a palliative setting

Question 2

Anti-psychotic 1st generation (typical)

Haloperidol, chlorpromazine, prochlorperazine

MOA

Answer 2

• Anti-psychotic drugs block post-synaptic dopamine D2 receptors
• There are 3 main dopeaminergic pathways in the CNS

1. The mesolimbic/mesocortical