Gonorrhoea

Question 1

Quinolones (Ciprofloxacin)

Common indications

Answer 1

• UTI
• Severe GI infections
• Lower respiratory tract infection
• Pseudomonas infection

Question 2

Quinolones (Ciprofloxacin)

MOA

Answer 2

• Quinilones kill bacteria by inhibiting DNA synthesis, they are particularly effective against aerobic G+ bacteria
• Bacteria rapidly develop resistance- by preventing the intracellular accumulation of the drug by reducing permeability and or efflux. Others develop protective mutations in target enzymes

Question 3

Quinolones (Ciprofloxacin)

Adverse effects

Answer 3

• GI upset
• Hypersensitivity
• Neurological effects
• Rupture of muscle tendons
• Prolonging the QT interval
• Arrhythmias
• C.dif

Question 4

Quinolones (Ciprofloxacin)

Warnings

Answer 4

• Seizures
• Who are growing
• Risk factors for QT prolongation

Question 5

Quinolones (Ciprofloxacin)

Interactions

Answer 5

• Drugs containing divalent cations reduce absorption and efficacy of quinolones
• Ciprofloxacin inhibits certain CYP P450 enzymes, increasing the risk of toxicity with some drugs notable theophylline
• Seizures, and of prednisolone increases the risk of tendon rupture
• Quinolones should be prescribed with caution in patients taking drugs that prolong QT interval or cause arrhythmias, such as amiodarone, SSRI, antipsychotic

Question 6

Quinolones (Ciprofloxacin)

Communication

Answer 6

• Allergy