Schizophrenia Flashcards

1
Q

neurotransmitter responsible for schizophrenia

A

dopamine (too much)

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2
Q

most likely time to be diagnosed with schizophrenia

A

early adulthood

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3
Q

what is schizophrenia

A

chronic relapsing condition of distorted thought, emotion, perception and behaviour

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4
Q

what are the 2 groups of symptoms in s

A

positive and negative

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5
Q

positive symptoms

A

delusions
hallucinations
thought disorder

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6
Q

negative symptoms

A
apathy
lack of volition (will power)
social withdrawal
cognitive impairment 
catatonia
loss of interest
self-absorbed attitude
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7
Q

most common hallucination in schizophrenia

A

third person auditory - giving a running commentary

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8
Q

what are thought disorders

A
thought insertion
throught broadcasting 
thought withdrawal 
knight's move thoughts
neologisms
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9
Q

diagnostic criteria for schizophrenia

A

1 positive symptom or 2 negative symptoms

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10
Q

what are Schneider’s first rank symptoms

A

symptoms very suggestive of schizophrenia:
auditory hallucinations (running commentary)
thought disorder
somatic hallucinations
delusional perception
passivity phenomena

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11
Q

how long must symptoms last for

A

1 month continuously

6 months if on/off

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12
Q

differentials for psychosis

A
drug induced 
depressive 
mania with psychosis 
schizoaffective disorder 
delirium
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13
Q

common drug that can cause psychosis

A

cannabis

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14
Q

manifestation of manic psychosis

A

delusions of grandeur, special ability, persecution, religiosity

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15
Q

what is schizoaffective disorder

A

patient experiences symptoms of an affective disorder (depression or mania) and psychosis within days of each other

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16
Q

how to differentiate delirium from schizophrenia

A

elderly

triad of acute onset, inattention with fluctuating course, altered consciousness/disorganised thinking

17
Q

if medication is required in delirium, what should be given

A

haloperidol

18
Q

when should antipsychotic medication be commenced

A

at diagnosis of schizophrenia/psychosis

19
Q

psychological interventions in schizophrenia

A

CBT
manage substance misuse
family therapy and support groups

20
Q

what are the two groups of antipsychositcs

A

typical (older)

atypical (newer)

21
Q

examples of typical antipsychotics

A

chlorpromazine

haloperidol

22
Q

examples of atypical antipsychotics

A

olanzapine
risperidone
quetiapine
clozapine

23
Q

what receptors do atypical antipsychotics work on

A

D2 antagonists and 5HT2A antagonists (more this)

24
Q

what receptor do typical antipsychotics work on

A

D2 agonists

25
which type of antipsychotic is first line
atypical
26
why are atypicals used first line
better side effect profile
27
what atypical is first line
olanzapine
28
what is next line management after olanzapine
another atypical then a typical then clozapine
29
SE of typical antipsychotics (D2 blockade)
extra-pyramidal (tardive syndromes, dyskinesias, parkinsonianism, neuroleptic malignant syndrome) hyperprolactinaemia sedation long QTc
30
what part of brain is affected in extra-pyramidal side effects
dorsal striatum
31
SE of atypical antipsychotics (5HT2 blockade)
metabolic syndromes
32
SE of histamine receptor block
sedation | increased appetite
33
side effect of muscarinic block
PARASYMPATHETIC | think eyes, salivary glands, bowel, bladder
34
when is clozapine used
resistant to other treatment
35
side effects of clozapine
``` sedation agranulocytosis (patient should come in if got a sore throat) myocarditis (if stopped suddenly) gastroparesis weight gain hypersalivation ```
36
what monitoring is required in clozapine treatment
weekly for first 6 months fortnightly for next 6 months every 4 weeks thereafter one month after stopping treatment
37
what anti-psychotics are not safe in pregnancy
clozapine | olanzapine