Dementia

Question 1

first part of brain affected in alzheimers

Answer 1

nucleus basilis of meynert

Question 2

neurotransmitter deficient in alzheimers

Answer 2

Ach

Question 3

4 drugs can use in alzheimers disease and what is there action

Answer 3

cholinesterase inhibitors
donepezil
galantamine
rivastigmine

NMDA antagonist
memantine

Question 4

gross brain changes in alzheimers

Answer 4

widening of sulci and narrowing of gyri

Question 5

micropathology of alzheimers

Answer 5

beta-amyloid protein (insoluble extracellular)
neurofibrillary tangles (insoluble intracellular)

Question 6

what codes for beta amyloid

Answer 6

APP gene

Question 7

what is apiloprotein e

Answer 7

glycoprotein

Question 8

what makes apiloprotein E and where are there high concs

Answer 8

made by glia

high conc in brain and liver

Question 9

what does apiloprotein E predispose to

Answer 9

alzheimers

Question 10

what test used in diagnosis of dementia

Answer 10

MMSE

Question 11

cut off scores in MMSE

Answer 11

<27 excludes dementia

>24 supports dementia

Question 12

abrupt onset of impaired cognitive function (memory, intelligence)
stepwise deterioration

Answer 12

vascular dementia

Question 13

alpha synuclein proteins

Answer 13

lewy bodies

Question 14

fluctuating cognition (varied attention and alertness) before movement problem
visual hallucinations
parkinsonianism

Answer 14

lewy body dementia

Question 15

behavioural changes
semantic dementia
progressive non-fluent aphasia

Answer 15

pick’s disease