Schizophrenia Flashcards
What is the prevalence of Schizophrenia?
1.1%
What can symptoms of Schizophrenia be characterised by?
Disturbances in the areas of the brain associated with thought, perception, attention, motor behaviour and emotion
What may Schizophrenia be accompanied with?
Cognitive deficit, anxiety, depression, self punishment
What signalling is involved with Schizo?
DA, glutamate, 5HT2A receptor agonists
What do Schizo brains tend to have?
Larger lateral ventricles and smaller left temporal lobe
What are the functions of the mesocortical and mesolimbic pathways?
Compulsion, reward pathways, perseverance, stereotypical behaviour effect
What is excess DA system associated with?
Schizophrenia, ADD, drug dependance
How many DA receptors are there, what are they and which ones are effected in Schizo?
GPCR, 5, the odd numbers (inhibitory ones)
How do amphetamines work?
Stimulate secretion of DA and other amines by inhibiting MAO on presynaptic terminals so inhibit DA and NA metabolism, displace DA and NA from vesicles so cause reuptake transporters to work in reverse
What are amphetamines used to treat?
Narcolepsy and ADHD
What are the names of the drugs that act on DA?
Phenothiazine- Dopamine D2 antagonist
What side effects are associated with first generation/typical antipsychotics?
Motor disturbances, extrapyramidal effects and prolactin
Give 2 examples of typical antipsychotics
Chlorpromazine, haloperidol
What did typical antipsychotics lead to?
Tardive dyskinesia
What examples are there of atypical antipsychotics?
Sulpride (D2), Clozapine(D1=D2, 5HT2A, mACh, H1, alpha 1), rispiridone (5HT2A, D2>D1, alpha 1, H1)
