Schizophrenia Flashcards
What is another term for schizophrenogenic mothers?
Refrigerator mothers
According to Fromm-Reichmann, what are the 3 main characteristics of schizophrenogenic mothers?
- Controlling
- Cold
- Rejecting
What do the contradicting messages from schizophrenogenic mothers cause?
- Creates tense atmosphere full of secrecy
- Leads to distrust and paranoid delusions, and later, schizophrenia
Outline Bateson’s double-bind theory
- Child may be trapped in situations where they feel they’re doing the wrong thing, but receive conflicting messages as to what counts as “wrong”
- Child cannot express feelings of unfairness about the situation
- When they “get it wrong” (often), the child is punished by withdrawal of love - they learn the world is confusing and dangerous, leading to disorganised thinking and delusions
What are the 3 main factors of expressed emotion (EE)?
- Verbal criticism of the person with schizophrenia
- Hostility towards the person with schizophrenia
- Emotional over-involvement from the parents towards the person with schizophrenia
What might high levels of EE cause in a person with schizophrenia?
Causes stress, which may lead to either an onset or a relapse of schizophrenia
Outline dysfunctional thought processing as a cognitive explanation for schizophrenia
- Lower levels of information processing in some areas of the brain suggest cognition is impaired.
- For example, reduced processing in the ventral striatum is associated with negative symptoms
Define metarepresentation, according to Frith et al.
The cognitive ability to reflect on thoughts and behaviour
What does metarepresentation lead to?
- This dysfunction disrupts our ability to recognise our thoughts as our own
- Could lead to the sensation of hearing voices (hallucination) and experience of having thoughts placed in the mind by others (thought insertion, a delusion)
What issues did Frith et al. find with the cognitive ability to suppress automatic responses while we perform deliberate actions?
- Speech poverty and thought disorder could result from the inability to suppress automatic thoughts and speech triggered by other thoughts
- For example, people with schizophrenia tend to experience derailment of thoughts because each word triggers associations, and the person cannot suppress automatic responses to these
There is evidence linking family dysfunction with schizophrenia. How is this a strength of psychological explanations of schizophrenia?
- A review by Read et al. reported that adults with schizophrenia are disproportionately likely to have insecure attachment (Type C or D)
- Also, 69% of women and 59% of men with schizophrenia have a history of physical and / or sexual abuse
- This strongly suggests that family dysfunction does make people more vulnerable to schizophrenia
There is a poor evidence base for any family-based theories. How is this a weakness of the family dysfunction explanation for schizophrenia?
- There is almost no evidence to support the importance of traditional family-based theories, e.g. schizophrenogenic mother and double bind
- Both theories are based on clinical observation of patients and informal assessment of the personality of the mothers of patients
- This means that family explanations have not been able to explain the link between childhood trauma and schizophrenia
Discuss parent-blaming as an evaluation point for the family dysfunction explanation for schizophrenia
- Research in this area may be useful, e.g. showing that insecure attachment and childhood trauma affect vulnerability to schizophrenia
- HOWEVER, research is socially sensitive because it can lead to parent-blaming. This creates additional stress for parents already seeing their child experience schizophrenia and taking responsibility for their care
- This means that research into family dysfunction and schizophrenia will always be very controversial, but worth it for potential benefits
There is evidence for dysfunctional thought processing. How is this a strength of the cognitive explanation for schizophrenia?
- Stirling et al. compared performance on a range of cognitive tasks, (e.g. Stroop task) in people with and without schizophrenia
- As predicted by central control theory, people with schizophrenia took over twice as long on average to name the font-colours
- This supports the view that the cognitive processes of people with schizophrenia are impaired
Only proximal origins of symptoms are explained. How is this a weakness of the cognitive explanation for schizophrenia?
- Cognitive explanations for schizophrenia are proximal explanations - they explain what is happening now to produce symptoms
- Cognitive explanations are weaker than distal explanations (i.e. what causes cognitive problems), possible distal explanations are genetic and family dysfunction
- This means that cognitive theories alone only provide partial explanations
Discuss whether schizophrenia is a biological or psychological condition as an evaluation point for the cognitive explanation for schizophrenia
- The cognitive approach provides an excellent explanation for the symptoms of schizophrenia, suggesting it is a psychological condition
- HOWEVER, abnormal cognition is probably partly genetic in origin and the result of abnormal brain development, according to Toulopoulou et al.
- This means that although it has psychological symptoms, schizophrenia is perhaps best seen as a biological condition
What is the dopamine hypothesis of schizophrenia?
An excess of dopamine is associated with the positive symptoms of schizophrenia
What do typical antipsychotics do to treat schizophrenia?
- Dopamine antagonists work by blocking dopamine receptors in the synapses in the brain, reducing the action of dopamine
- Initially, dopamine levels build up after taking chlorpromazine, but then production is reduced
- This normalises neurotransmission in key areas of the brain, which in turn reduces symptoms like hallucinations
How does the sedation effect of Chlorpromazine impact people with schizophrenia?
Acts on histamine receptors, which reduces anxiety
What are the 3 ways in which Chlorpromazine can be administered?
- Tablets
- Syrup
- Injection
What is the maximum dosage of Chlorpromazine?
1000mg
What is the typical dosage of Chlorpromazine?
400mg - 800mg
What are the 2 ways that Clozapine is typically administered?
- Tablets
- Syrup
What is the typical dosage of Clozapine?
300mg - 450mg
Why isn’t Clozapine administered through injection anymore?
It caused a fatal blood condition in some patients called agranulocytosis
What are the aims of atypical antipsychotics?
- Maintain or improve upon the effectiveness of drugs in suppressing the symptoms of psychosis
- Minimise the side effects of the drugs used
What do atypical antipsychotics do?
- Binds to dopamine receptors as Chlorpromazine does but also acts on serotonin and glutamate receptors
- Clozapine reduces depression and anxiety as well as improving cognitive functioning
- It also improves mood, which is important as up to 50% of people with schizophrenia attempt suicide