SCC Flashcards
what is SCC
proliferation of atypical, transformed keratinocytes in the skin with malignant behaviour
is SCC benign or malignant
malignant
what are the different types of SCC
1 actinic keratosis (precursor to SCC)
2 Bowens disease
3 invasive SCC
4 metastatic SCC
what are precursor lesions to SCC
actinic (sun-damage) keratosis
what are non-melanoma skin cancers referred to as
keratinocyte cancers
how common non-melanoma skin cancers (keratinocyte cancers)
most common skin cancer class
what are the 2 most common keratinocyte cancers
1 BCC
2 SCC
which normally is benign and which normally metastases between BCC and SCC
BCC - benign
SCC - malignant
epi
common in sun exposed skin
middle age
men>women
risk factors
fair skin
excessive sun exposure or UV exposure
radiation
which form of UV radiation is most associated for formation of SCC
UV B (290-320nm)
pathogenesis
mutations to DNA of keratinocytes which causes uncontrolled proliferation and transformation
where is bowens disease confined to
outer layer of skin
where has invasive SCC spread
into deeper layers of skin but not body
where has metastatic SCC spread
into deeper layers of skin and body
history
slow growing mass which is rough and scaly, on the skin which may be bleeding or crusting
often looks like a large wart and may have a raised crusted surface
what is a keratoacanthoma
a rapidly growing dome shaped nodule with a central crater
what is the first line investigation for SCC
biopsy which shows keratinocyte atypia
what might there be a history of in SCC
skin cancer
A 70-year-old previously healthy white man presents with multiple, hyperkeratotic, scaly papules on the face, scalp, and hands. Some papules have grown to become larger nodules that sometimes bleed and fail to heal. In the past he has had significant sun exposure including multiple blistering sunburns. Previously, he has had skin cancer on the face.
SCC
