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ENR Biweekly 2 > Scammell- pharmocological Rx of breast cancer > Flashcards

Scammell- pharmocological Rx of breast cancer Flashcards

1
Q

does combination birth control pills for premenopausal patients have a link to breast cancer

A

no

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2
Q

does topical vaginal estrogen products have a link to breast cancer in peri and post-menopausal patients

A

no

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3
Q

increases risk of breast cancer BUT reduces risk of endometrial cancer

A

progestin

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4
Q

____ approved that is an estrogen antagonist at breast and endometrium while getting estrogen benefits elsewhere

A

SERM

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5
Q

hormonal therapy taken for ____ years for breast cancer treatment

A

5-10

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6
Q

selective estrogen receptor modulator (SERM) used to treat breast cancer in premenopausal women

A

Tamoxifen

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7
Q

increased risk of endometrial cancer and blood clots with this medicine

A

Tamoxifen

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8
Q

aromatase inhibitor used to treat breast cancer in postmenopausal women

A

Letrozole, Anastrazole

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9
Q

won’t see estrogenic effects with _____ inhibitors b/c estradiol levels are low

A

aromatase

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10
Q

SE of hormonal therapy

A

menopausal symptoms, risk of endometrial cancer and blood clots

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11
Q

___ promotes the growth of cancers that are estrogen receptor +

A

estrogen

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12
Q

hormone receptor + means ___ and ___ receptor +

A

estrogen and progesterone

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13
Q

___ increases progesterone receptor synthesis, so ____ receptor + tissues have both ER and PR

A

estrogen

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14
Q

stop estrogen from acting (SERM or SERD) OR
lower estradiol levels (aromatase inhibitor) OR
inhibit estradiol secretion

A

hormone therapies

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15
Q

if the cancer is ER- and PR-, ___ therapy is ineffective

A

hormone

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16
Q

Estrogens agonists at some tissues, BUT
estrogens antagonists at others

A

SERM (selective estrogen receptor modulators)

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17
Q

to treat ER + breast cancer: antagonist at the breast; agonist at the endometrium and clotting factors (endometrial cancer and blood clot risks)

A

Tamoxifen

18
Q

SERM that is pro-fertility, antagonist at hypothalamus and increase in GnRH

A

Clomiphene

19
Q

SERD (selective ER depleter or down-regulator); blocks the estrogen receptor and the receptor is degraded intracellularly
Second-line therapy in metastatic breast cancer after initial failure

A

Fulvestrant

20
Q

SE of this drug is hot flashes and night sweats due to antagonism of some effects of estrogen

A

Fulvestrant

21
Q

letrozole, anastrazole, exemestane

A

aromatase inhibitors

22
Q

used in premenopausal women for fertility induction + postmenopausal women for breast cancer treatment

A

Letrozole, Anastrazole

23
Q

SE of aromatase inhibitors

A

bone thinning, osteoporosis

24
Q

acts at GnRH receptor and downregulates entire pathway; decreases FSH secretion and decreases estradiol

A

Leuprolide

25
Q

feedback at hypothalamus and pituitary to decrease FSH secretion; decrease FSH secretion and decrease estradiol

A

progestin and androgen

26
Q

is expressed on 20% of breast cancer cells and stimulates growth

A

HER2

27
Q

monoclonal antibody to HER2
Main side effect is cardiovascular especially if combined with doxorubicin

A

Trastuzumab (Herceptin)

28
Q

targets HER2 but at a different site than trastuzumab; given together for synergistic effect

A

Pertuzumab

29
Q

the monoclonal antibodies to treat breast cancer can be used with what other 2 inhibitors

A

tyrosine kinase inhibitor
CDK 4/6 inhibitor

30
Q
A

do not get chemo

31
Q

topoisomerase II inhibitor used to treat triple - breast cancer

A

doxorubicin

32
Q

main toxicity of doxorubicin

A

cardiac

33
Q

stabilizes microtubules; used to treat triple - breast cancer

A

paclitaxel

34
Q

main SE of paclitaxel

A

neuropathy

35
Q

inhibits thymidylate synthase; used to treat triple - breast cancer

A

5–fluorouracil

36
Q

main SE of 5-fluorouracil

A

neurotoxicity

37
Q

alkylates DNA; used to treat triple - breast cancer

A

cyclophosphamide

38
Q

main SE of cyclophosphamide

A

hemorrhagic cystitis

39
Q

Inhibit osteoclastic activity, decrease bone turnover; used in osteoporosis, bone pain and bone metastasis of breast cancer

A

bisphosphonates

40
Q

Monoclonal Ab that inhibits osteoclast activity by binding to RANK; used in osteoporosis and bone pain for bone metastasis of breast cancer

A

Denosumab

ENR Biweekly 2 (11 decks)

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