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ENR Biweekly 2 > Audia- infections of reproductive tract > Flashcards

Audia- infections of reproductive tract Flashcards

1
Q

love to live in area of belt line and very easily transmitted; cause infectious disease of reproductive tract

A

scabies and genital lice

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2
Q

presence of inflammation in vagina

A

vaginitis

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3
Q

infection of vagina w/ the absence of inflammation

A

vaginosis

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4
Q

antibiotic that inhibits cell wall synthesis

A

Ceftriaxone

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5
Q

antibiotic that uses ROS to inhibit nucleic acid synthesis

A

Metronidazole

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6
Q

antibiotic that inhibits protein synthesis by blocking 50S ribosome reversibly

A

Azithromycin

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7
Q

pH of vagina

A

acidic

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8
Q

most common microbes in vagina

A

lactobacillus species

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9
Q

age, diet, and menstrual cycle contributes to ______ of the vagina

A

microbiome

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10
Q
A

NAAT

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11
Q

gram - like; no peptidoglycan
no gram stain
obligate intracellular

A

Chlamydia trachomatis

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12
Q

what immunotypes of chlamydia are associated with STI

A

D-K

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13
Q

____ bodies of Chlamydia are infectious and do not replicate

A

elementary

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14
Q

____ bodies of Chlamydia are noninfectious and replicate

A

reticulate

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15
Q

prevalence of ____ is higher in females than males

A

Chlamydia

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16
Q

non-gonococcal urethritis
pelvic inflammatory disease
reactive arthritis

A

Chlaymida

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17
Q

main way to diagnose Chlamydia

A

presentation of sx’s and NAAT

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18
Q

how to treat chlamydia

A

Azithromycin; Doxycycline

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19
Q

likely cause?

A

Neisseria gonorrhoeae

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20
Q

gram - diplococci
kidney bean shape
neutrophils with this pathogen inside it

A

N. gonorrhoeae

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21
Q

Grow on chocolate agar or Thayer martin (chocolate agar with antibiotics on it that prevent outgrowth of normal flora)

A

N. gonorrhoeae

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22
Q

equal prevalence in males and females

A

Gonorrhea

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23
Q

burning w/ urination
purulent discharge
self-limiting, but if persists can lead to fibrosis of urethra

A

Gonorrhea

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24
Q

Gonorrhea is often asymptomatic in ______

A

females

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25
Direct spreading to fallopian tubes; infection of peritoneum; Fibrosis of the fallopian tube (Sterility) Salpingitis Endometritis Peritonitis
Gonorrhea
26
cervicitis
27
asymptomatic _____ are primary reservoir of this
females
28
Odds are if they are infected with one STI, they will be infected with
more than one
29
can lead to blindness in babies eye (not trans-placental, but from physical exposure in birth canal); ocular infection
Gonorrhea transmission from mother to baby
30
use pili to attach to epithelial cells pili can undergo phase variation to stay one step ahead of immune system
Gonorrhea
31
cytotoxin (NLRs)------cytokine storm endotoxin (LOS)-----binds TLR4 and release of TNF alpha
Gonorrhea
32
organism binds to factor H inhibiting complement cascade
gonorrhea
33
usually does not disseminate, but if it does, can cause petechial rash or purulent arthritis
Gonorrhea
34
for men, gram stain of discharge is used to diagnose _____
Gonorrhea
35
for women, gram stain and culture or PCR test to diagnose ____
gonorrhea
36
how to treat gonorrhea
Ceftriaxone (Rocephin injection) and Azithromycin
37
syphilis
38
darkfield microscopy PAINLESS lesions
Syphilis
39
what causes Syphilis
Treponema pallidum
40
corkscrew shape on microscopy no gram stain human reservoir
Syphilis
41
more common in men
syphilis
42
Syphilis
43
transmit through sex AND transplacental
Syphilis
44
highly infectious, hard, painless ulcer (chancre) with raised borders on genitalia or mouth, regional lymphadenopathy
primary syphilis
45
lesions all over body, palms, soles "the Great Imitator"
secondary syphilis
46
differential
HPV secondary syphilis
47
neuro, CV, GUMMAS (on liver, bones, or other internal organs); gummas (granulomatous lesions, if immune system cant kill it, will wall it off)
tertiary syphilis
48
gummas
49
Neurosyphilis
50
neurosyphilis
51
3rd most common STD in the US Stays quiet and hidden!!!!!!!!!!!
syphilis
52
to diagnose syphilis
darkfield microscopy RPR (rapid plasma reagin)
53
RPR test for syphilis
54
to treat syphilis
Penicillin G
55
reaction to antibiotics due to lysis of organsim
JH reaction (Jarisch-Herxheimer)
56
PAINFUL lesions (not in clusters)
Chancroid (due to Haemophilus)
57
to treat Chancroid
ceftriaxone
58
cause what
Urethritis
59
to treat non-gonoccal/chlamydial urethritis
Azithromycin or doxycycline
60
not sexually transmitted balance of microbiota disrupted no inflammation
Bacterial Vaginosis
61
most have no symptoms, but can have: fish-like odor thin discharge itching can lead to spontaneous abortion
Bacterial Vaginosis
62
Bacterial Vaginosis
63
bacterial vaginosis mainly caused by what
Gardnerella vaginalis
64
to treat Bacterial Vaginosis
Flagyl (metronidazole)
65
trichomoniasis
66
One of the TORCH organisms associated with neonatal infections strawberry cervix, green-grey discharge can have urethritis
Trichomoniasis
67
cause of trichomoniasis
Trichomonas vaginalis
68
to diagnose trichomoniasis
wet mount of discharge and Whiff test
69
to treat trichomoniasis
flagyl (metronidazole)
70
what to do when you see one STD
test for others
71
cottage-cheese like vaginal discharge itching dysuria
vulvovaginal candidiasis
72
budding yeast on wet mount of discharge
Candida albicans
73
to treat vulvovaginal candidiasis
topical antifungals Monostat oral antifungals (fluconazole)
74
genital herpes
75
double stranded DNA virus, enveloped
HSV
76
interferes with MHC I presentation of antigen
HSV
77
PAINFUL lesions (ulcerative, vesicular, clustered) tender lymphadenopathy fever, malaise
HSV
78
can give to baby by physical contact with birthing canal TORCH organism
HSV
79
to diagnose HSV
PCR (viral culture)
80
nucleoside analongs that are DNA polymerase inhibitors
Penciclovir Acyclovir
81
used to treat herpes
antivirals (nucleoside analogs)
82
Condyloma acuminata (HPV)
83
cause of cervical warts (condyloma acuminata)
HPV 6, 11, 16, 18
84
double strand DNA virus
HPV
85
serotypes of HPV that have high risk for cervical cancer
16 and 18
86
common skin warts HPV serotypes
2 and 4
87
"stuck on lesions" fleshy soft outgrowths
Condyloma acuminata
88
HPV infects actively dividing _____ cells
basal epithelial
89
2 important viral encoded proteins that HPV makes; they dysregulate host cell cycle
E6 and E7
90
___ and ___ inhibit P53 and Rb so breaks are off cell cycle and leads to dysregulation and more cell division
E6 and E7
91
vaccine for HPV
Gardasil
92
to treat HPV (procedures)
cryotherapy excision laser
93
topical antiviral for HPV
5-fluorouracil
94
topical immunotherapy cream for HPV that activates TLR7
Imiquimod cream

ENR Biweekly 2 (11 decks)

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