SBG Rabbit Qs_BBCh9 Flashcards
What is the full taxonomic classification of the domesticated rabbit?
A: class Mammalia, order Lagomorpha, family Leporidae, subfamily Leporinae, Oryctolagus cuniculus
- Which genera represent hares?
Lepus
- ____________ deficiency in rabbits is a model of _______________ in humans.
vitamin A; hydrocephalus
Acute respiratory distress syndrome can be be induced in rabbits how?
phorbol myrisate acetate
Name six cancer models of rabbits as listed by the AFIP.
VX-2 carcinoma tumor, spontaneous endometrial adenocarcinoma, monoclonal gammopathies, nephroblastoma, lymphoblastic leukemia, malignant fibroma
The VX-2 carcinoma arises from malignant transformation of __________________.
viral-induced Shope papilloma
What serological abnormality is evident with the VX-2 carcinoma within 4 weeks of implantation?
fulminating hypercalcemia
What is the approximate incidence of spontaneous endometrial adenocarcinoma in rabbits 5 years of age or older?
79% or higher
- How is nephroblastoma induced in rabbits?
A: ethylnitrosurea to pregnant does
- How is the rabbit model of beta-lymphoblastic leukemia created?
transgenic rabbit line which develops disease as weanlings
- What is the WHHL rabbit, how is it unique, and what does it model?
A: Wantanabe heritable hyperlipidemic rabbit; has marked deficiency of LDL receptors in liver and other tissues; selective breeding of WHHL rabbits will increase incidence of coronary artery atherosclerosis without increasing aortic atherosclerosis; used to study cholesterol metabolism and atherosclerosis
- What is the St. Thomas Hospital rabbit strain, how is it unique and what does it model?
A: used to study cholesterol metabolism; has normal functioning LDL receptors but maintains a hypercholesterolemic state
- The absence of second incisors (peg teeth) in rabbits in some rabbits herds is a __________ trait.
dominant
Which salivary gland in rabbits does not have a human counterpart?
zygomatic
T/F Mucous glands are a prominent feature of the rabbit esophagus.
False; no mucous glands in rabbit esophagus
Describe the musculature of the rabbit esophagus and stomach.
three layers of striated muscle that extend the length of esophagus including cardia of stomach; this is in contrast to humans and many other species who have separate portions of striated and smooth muscle along esophagus
T/F The stomach is never entirely empty in a healthy rabbit.
True; gastric contents often include ingested hair as part of normal grooming
Most of the maternal immunity that kits receive is active or passive?
passive via the yolk sac; the GI tract of rabbits is relatively impermeable to large molecules
- Describe the content of cecotrophs.
high moisture content, rich in nitrogen-containing compounds, contain B vitamins niacin, riboflavin, pantothenate, cyanocobalamin.
- Respiratory effort in rabbits is due mainly to what musculature?
A: diaphragm
T/F Compression and release of the chest wall in rabbits 30-45 times per minute is the most effective means of artificial respiration.
False; that method is ineffective due to the diaphragm being the primary muscle responsible for respiratory effort; artificial respiration is best performed by alternating the head up and down 30-45 times per minute while holding the animal
How many lobes of the rabbit lung?
6; cranial, middle and caudal on each side
T/F Lung volume in rabbits increases with age.
True; unlike in humans and dogs where lung volume decreases with age
What is unique about the rabbit heart compared to other mammals?
tricuspid valve has two cusps
T/F The aortic nerve in the rabbit responds to baroreceptors only.
True; the aortic nerve in rabbits subserved no known chemoreceptors.
T/F Blood supply to the rabbit brain is supplied mainly by the internal carotid arteries.
True; blood supply by the vertebral arteries is limited
T/F The rabbit kidney is unipapillate making renal cannulization more difficult.
False; the rabbit kidney is unipapillate but this facilitates cannulization
T/F The number of glomeruli in rabbits increase after birth.
True; unlike humans where all glomeruli are present at birth
Describe the clearance of creatinine in rabbit relative to insulin.
they are identical
GFR can be accurately measured in rabbits by measuring clearance of ____________.
creatinine