BB LRGPHOR Ch12 - Toxicity Testing in Rabbits Flashcards
1
Q
- The domestic rabbit used in research is
A
Oryctolagus cuniculus
2
Q
- Breeds of rabbits commonly used in research include
a. New Zealand White
b. Japanese albino
c. Dutch Belted
d. all of the above
A
d
3
Q
- Advantages of using the Dutch Belted rabbit over the albino rabbits is
a. smaller size of Dutch Belted requires about 40% less test material
b. effects of test materials on melanocytes may be studied
c. a and b
d. none of the above
A
c
4
Q
- True or False: Himalayan rabbits, primarily used in Europe, have reproductive data similar to other breeds used in research.
A
True
5
Q
- Other breeds sometimes used in research include
a. Flemish Giant
b. Polish
c. Red Burgundy
d. all of the above
A
d
6
Q
- True or False: Stepwise acclimitation to once-daily limited feeding is commonly done prior to experimental procedures to avoid gastrointestinal upset, diarrhea, and poor health.
A
True
7
Q
- True or False: Rabbits may be a better model than rats to study hepatotoxicity of antibiotics in humans.
A
True
8
Q
- The following are suitable models of toxic shock syndrome due to Staphylococcus aureus
a. New Zealand White rabbit
b. Dutch-Belted rabbit
c. baboon
d. a and c
A
d
9
Q
- True or False: Ochratoxin A and Citrinin are two mycotoxins formed in improperly stored feed. These toxins are nephrotoxic in animals and have been shown to be immunotoxic in New Zealand White rabbits.
A
True
10
Q
- In vitro models developed in rabbits to investigate nephrotoxicity include
a. isolated perfused kidney
b. isolated glomeruli and isolated perfused tubules
c. renal cortical slices and proximal tubule cell cultures
d. all of the above
A
d
11
Q
- Because the rabbit renal system is sensitive to contrast agents, in vivo rabbit models have been useful to evaluate toxicity of contrast being developed for use in
a. radiography
b. ultrasound
c. computed tomography
d. all of the above
A
d
12
Q
- True or False: Due to differences in renal accumulation, compared to mice and rats, rabbits are more sensitive to nephrotoxic effects of cephalosporins.
A
True
13
Q
- Single i.v. injection of cephaloridine in New Zealand White (NZW) rabbits results in
a. bilateral proximal convoluted tubule necrosis
b. aminoaciduria and lactic aciduria
c. glycosuria
d. all of the above
A
d
14
Q
- The rabbit has proven a useful model for
a. cyclosporine A nephrotoxicity
b. rapamycin nephrotoxicity
c. cephalosporin nephrotoxicity
d. all of the above
A
d
15
Q
- Rabbits are considered a relevant animal model of Alzheimer disease because
a. rabbits consistently develop neurofibrillary tangles
b. rabbits are sensitive to aluminum induced neurotoxicity
c. rabbits develop cognitive dysfunction
d. all of the above
A
d
16
Q
- True or False: A rabbit model has been used to elucidate the mechanism of methotrexate teratogenicity and to investigate protective strategies.
A
True