Sample Questions 1st Assess Flashcards
Botulinum toxin is a large protein molecule. Its action on cholinergic trasnmission depends on am intracellular action within nerve endings. W/c one of the ff proccess is best suited for permeation of very large protein molecules into cells?
A. Aqueous diffusion
B. Aqueous hydrolysis
C. Endocytosis
D. DPecial carrier transport
ENDOCYTOSIS
Sugammadex is a new drug that reverses the action of rocuronium and certain other skeletal muscle-relaxing agents. It appears to interact directly with the rocuronium molecule and not at all with the rocurnium receptor. W/c describes sugammadex?
Chemical antagonist
A 60 y.o px w/ severe cancer pain is given 10mg of morphine by mouth. The plasma conc. is found to be only 30% of that found after intravenous administration of the same dose. W/c term describes the process by w/c the amount of the active drug in the body is reduced after administration but before entering the systemic circulation?
First-pass effect
DRUG SAFETY CATEGORY
Controlled studies in women fail to demonstrate a risk to the fetus in the 1st trimester and the possibility of fetal harm appears remote
Category A
Either animal reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women, or animal reproduction studies have shown adverse effect that was not confirmed in the controlled studies in women in the 1st trimester
Category B
Either studies in animals have revealed adverse effects on the fetus and there are no controlled studies in women
Category C
There is positive evidence of human fetal risk but the benefits from use in pregnant women may be acceptable
Category D
Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience or both
Category X
A 20-year-old man is using an albuterol inhaler for frequent episodes of asthma and complains of symptoms that she ascribes to albuterol. Which of the following is not a recognized action of albuterol?
A. Diuretic effect B. Positive inotropic effect C. Skeletal muscle tremor D. Smooth muscle relaxation E. Tachycardia
Diuretic effect
An 11-year-old child has severe asthma and was hospitalized several times already. He is now receiving medications that reduced the frequency of severe attacks. Which of the following is most likely to have adverse effects when used daily for a long period of time?
a. Albuterol by aerosol b. Beclomethasone by aerosol c. Ipratropium by inhaler d. Prednisone by mouth
Prednisone by mouth
One effect that theophylline, nitroglycerin, isoproterenol, and histamine have in common is:
Tachycardia
Which of the following does not have a bronchodilator effect?
a. Epinephrine
b. Terbutaline
c. Prednisone
d. Theophylline
e. Ipratropium
Prednisone
Which of the following is not an established prophylactic strategy for asthma?
a. Avoidance of antigen exposure
b. Blockade of histamine receptors
c. Blockade of leukotriene receptors
d. Ige antibody blockade
e. Inhibition of phospholipase A2
Blockade of histamine receptors
W/c of the ff is a bronchodilator useful in COPD and least likely to cause cardiac arrythmia?
a. cromolyn
b. ipratopium
c. salmetrol
d. epinephrine
cromolyn?
W/c is a direct bronchodilator that is most often used in asthma by the oral route and is capable of causing insomia and seizures?
Theophylline
