Salivary Gland Disorders Flashcards

1
Q

List the 8 non-neoplastic disorders of salivary gland origin.

A
  1. Mucocele/Ranula
  2. Sialothiasis
  3. Acute/chronic sialadenitis
  4. Sialadenosis
  5. Xerostomia
  6. Benign lymphoepithelial lesion (BLEL)
  7. Sjögren syndrome
  8. Necrotizing sialometaplasia
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2
Q

What causes a mucocele?

A

Rupture of salivary gland duct -> spillage of mucin

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3
Q

In what age group and at what location are mucoceles the most common?

A

Children/young adults; lower lip

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4
Q

What is a distinctive clinical feature of a mucocele?

A

Translucent to bluish hue

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5
Q

A __________ is a type of mucocele seen on the floor of the mouth, and arises from the sublingual gland.

A

Ranula

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6
Q

T/F: All mucoceles are treated with marsupialization.

A

False

Just Ranulas - making incision into the lesion and suturing the edges

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7
Q

Which gland is most often affected with sialolithiasis?

A

Submandibular gland (80%)

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8
Q

What is a lithotripsy?

A

A way to retrieve some sialolithiasis in major glands

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9
Q

What is acute/chronic sialadenitis?

A

Inflammation of salivary gland

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10
Q

What common microorganisms cause sialadenitis?

A

Bacteria - staph

Viral - mumps

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11
Q

Which glands are most often associated with sialadenitis?

A

Acute - parotid (pus coming from duct)

Chronic - submandibular

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12
Q

What allows you to differentiate between sialadenitis and a sialolith?

A

Radiograph

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13
Q

T/F: Sialadenosis is due to an infection.

A

False

Associated with underlying condition - diabetes, malnutrition, alcoholism, bulimia

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14
Q

What conditions does xerostomia predispose a patient to?

A
  1. Mucosal injury due to lack of lubrication
  2. Candidiasis
  3. Increased cervical caries
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15
Q

T/F: A patient on several different drugs is at more risk for xerostomia.

A

True

Esp. Antihistamines, antidepressants, sedatives, antihypertensives

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16
Q

T/F: Frothy saliva is a sign of xerostomia.

A

True

17
Q

Which lesion can be characterized by “blossoms on a tree” look in a radiograph?

A

BLEL

18
Q

In which disorder do you see remnants of ductal epithelium in the form of epimyoepithelial islands?

A

BLEL

19
Q

T/F: Sjögren syndrome is sometimes thought of as a continuation of BLEL.

A

True

20
Q

What is the difference between primary and secondary Sjögren syndrome?

A

Primary (sicca) - xerostomia and keratoconjunctivitis

Secondary - sicca plus another autoimmune disease

21
Q

T/F: Sjögren syndrome has a male predilection.

A

False

More common in females

22
Q

T/F: Serology is a specific test for Sjögren syndrome.

A

False

Is often used as diagnostic tool but is non-specific

23
Q

Which antibodies can help diagnose Sjögren syndrome?

A

Elevated IgG, rheumatoid factor, anti-nuclear autoantibodies, anti-SS-A, anti-SS-B

24
Q

What histopathogical features can be used to diagnose Sjögren syndrome?

A

Labial salivary gland biopsy

Looking for aggregates of >50 lymphocytes and plasma cells in a gland

25
Q

T/F: Patients with Sjögren syndrome have a 44x increase in lymphoma.

A

True

26
Q

What is thought to be the cause of Necrotizing sialometaplasia?

A

Due to ischemic necrosis from a variety of causes (traumatic injury, dental injection, ill fitting dentures)

27
Q

T/F: Necrotizing sialometaplasia is often seen in children.

A

False

Rare in children

28
Q

What is the most common location for necrotizing sialometaplasia?

A

Hard/soft palate

29
Q

How does necrotizing sialometaplasia typically present?

A

Sharply demarcated ulcer on the palate

Patient may say “piece of my palate fell out”

30
Q

Which salivary gland disorder can be easily mistaken for SCC histopathologically?

A

Necrotizing sialometaplasia

31
Q

Pseudoepitheliomatous hyperplasia (PEH) of surface epithelium is a characteristic of which salivary gland disorder?

A

Necrotizing sialometaplasia