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AU18: Oral Path 2 > HPV (4) > Flashcards

HPV (4) Flashcards

1
Q

Which two HPV types are not sexually transmitted?

A

HPV 6, 11: squamous papilloma

HPV 2: non-genital warts

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2
Q

T/F: HPV 6, 11 (venereal warts/squamous papillomas) are high risk for cancer.

A

False

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3
Q

T/F: HPV 16, 18 are high risk for cancer and sexually transmitted.

A

True

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4
Q

What is the most common soft tissue mass coming from the soft palate?

A

Squamous papilloma (HPV 6, 11)

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5
Q

T/F: Recurrence is likely with a squamous papilloma.

A

False

Conservative excision and not likely to recur

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6
Q

T/F: Verruca vulgaris (HPV 2) is commonly seen intraoraly.

A

False

Common on skin

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7
Q

How are skin lesions and oral lesions of verruca vulgaris treated?

A

Skin: topical therapy, surgery

Oral: surgery, laser, cryotherapy, electrosurgery

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8
Q

T/F: Verruca vulgaris may recur.

A

True

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9
Q

T/F: Condyloma acuminatum (HPV 6, 11) is a STI that has high cancer risk.

A

False

Low cancer risk

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10
Q

What is a way to differentiate squamous papilloma from condyloma acuminatum?

A

Condyloma acuminatum are often larger and seen in multiples

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11
Q

T/F: Anogenital condylomata infected with HPV 16, 18 have higher risk for SCC.

A

True

Oral lesions have not shown this

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12
Q

T/F: HPV infects basal cells.

A

True

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13
Q

T/F: Over 90% of HPV infections are cleared by the body within 2-3 years.

A

True

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14
Q

What proteins are made by HPV infected cells?

A

E6,E7: allow cell to grow uncontrolled

L1, L2: comprise virus capsid required for transmission, spread, survival

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15
Q

HPV makes up what percentage of oropharyngeal cancers?

A

70%

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16
Q

T/F: There is no consistent evidence that HPV is a risk factor for oral squamous cell carcinoma.

A

True

Less than 5% OSCC caused by HPV

17
Q

Which areas are considered oropharyngeal squamous cell carcinoma?

A

Base of tongue, soft palate, tonsils, pharyngeal wall

Cancers in this region heavily related to HPV

18
Q

T/F: OSCC has a better prognosis than OPSCC.

A

False

OSCC: 40% survival

OPSCC: 80% survival

19
Q

T/F: Incidence of HPV+ OPSCC is increasing.

A

True

20
Q

What constitutes HPV+ OPSCC diagnosis?

A
  1. Presence of HPV-16
  2. E6, E7 in tumor cells
  3. E6, E7 antibodies in serum
21
Q

What are the treatments for HPV+ OPSCC?

A

Early: platinum-based chemoradiotherapy

Late: surgery, chemo, radiation

22
Q

What is the prognosis of HPV+ OPSCC?

A

Good

Worse for HPV- and if patient is smoker

23
Q

Why is HPV testing important for OPSCC patient?

A

Identify patients that should have treatment de-escalated

24
Q

T/F: HPV vaccines can provide protection from all HPV types.

A

False

25
Q

T/F: HPV vaccines provide protection against HPV previously acquired through sexual activity.

A

False

26
Q

T/F: HPV vaccine is a treatment for genital warts and HPV-related cancer.

A

False

AU18: Oral Path 2 (18 decks)

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