HPV (4) Flashcards
Which two HPV types are not sexually transmitted?
HPV 6, 11: squamous papilloma
HPV 2: non-genital warts
T/F: HPV 6, 11 (venereal warts/squamous papillomas) are high risk for cancer.
False
T/F: HPV 16, 18 are high risk for cancer and sexually transmitted.
True
What is the most common soft tissue mass coming from the soft palate?
Squamous papilloma (HPV 6, 11)
T/F: Recurrence is likely with a squamous papilloma.
False
Conservative excision and not likely to recur
T/F: Verruca vulgaris (HPV 2) is commonly seen intraoraly.
False
Common on skin
How are skin lesions and oral lesions of verruca vulgaris treated?
Skin: topical therapy, surgery
Oral: surgery, laser, cryotherapy, electrosurgery
T/F: Verruca vulgaris may recur.
True
T/F: Condyloma acuminatum (HPV 6, 11) is a STI that has high cancer risk.
False
Low cancer risk
What is a way to differentiate squamous papilloma from condyloma acuminatum?
Condyloma acuminatum are often larger and seen in multiples
T/F: Anogenital condylomata infected with HPV 16, 18 have higher risk for SCC.
True
Oral lesions have not shown this
T/F: HPV infects basal cells.
True
T/F: Over 90% of HPV infections are cleared by the body within 2-3 years.
True
What proteins are made by HPV infected cells?
E6,E7: allow cell to grow uncontrolled
L1, L2: comprise virus capsid required for transmission, spread, survival
HPV makes up what percentage of oropharyngeal cancers?
70%
T/F: There is no consistent evidence that HPV is a risk factor for oral squamous cell carcinoma.
True
Less than 5% OSCC caused by HPV
Which areas are considered oropharyngeal squamous cell carcinoma?
Base of tongue, soft palate, tonsils, pharyngeal wall
Cancers in this region heavily related to HPV
T/F: OSCC has a better prognosis than OPSCC.
False
OSCC: 40% survival
OPSCC: 80% survival
T/F: Incidence of HPV+ OPSCC is increasing.
True
What constitutes HPV+ OPSCC diagnosis?
- Presence of HPV-16
- E6, E7 in tumor cells
- E6, E7 antibodies in serum
What are the treatments for HPV+ OPSCC?
Early: platinum-based chemoradiotherapy
Late: surgery, chemo, radiation
What is the prognosis of HPV+ OPSCC?
Good
Worse for HPV- and if patient is smoker
Why is HPV testing important for OPSCC patient?
Identify patients that should have treatment de-escalated
T/F: HPV vaccines can provide protection from all HPV types.
False
T/F: HPV vaccines provide protection against HPV previously acquired through sexual activity.
False
T/F: HPV vaccine is a treatment for genital warts and HPV-related cancer.
False
