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AU18: Oral Path 2 > Bone Disorders (3) > Flashcards

Bone Disorders (3) Flashcards

1
Q

What are the four inherited bone disorders?

A
  1. Osteogenesis imperfecta
  2. OSteopetrosis
  3. Cleidocranial dysplasia
  4. Cherubism
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2
Q

What are the six acquired bone disorders?

A
  1. Osteitis deformans (Paget disease)
  2. Fibro-Osseous dysplasia
  3. Cemento-Osseous dysplasia
  4. OSteoporotic bone marrow defect
  5. Idiopathic osteosclerosis
  6. Simple bone cyst
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3
Q

__________ leads to abnormal bone mineralization and low bone density (osteopenia) in osteogenesis imperfecta.

A

Defective collagen

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4
Q

T/F: 90% of osteogenesis imperfecta is autosomal dominant.

A

True

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5
Q

What are some clinical features of OI?

A

Fragile bones, blue sclera, hearing loss

CL III occlusion, triangular faces

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6
Q

T/F: Osteogenesis imperfecta and dentinogenesis imperfecta are the same disease.

A

False

Similar features but different mutations

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7
Q

____________ involves failure in osteoclast function which leads to increased bone density.

A

Osteopetrosis

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8
Q

Why are patients with osteopetrosis more susceptible to infections and osteomyelitis?

A

Loss of hematopoietic precursor cells (pancytopenia)

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9
Q

T/F: Patients with the autosomal dominant form of osteopetrosis typically die before 20 y.o.

A

False

Autosomal recessive is worse prognosis

Can live long with autosomal dominant

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10
Q

What are the clinical features of Cleidocranial dysplasia?

A

Prominent forehead, long neck, narrow and drooping shoulders

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11
Q

T/F: Patients with cleidocranial dysplasia are often missing several teeth.

A

False

Teeth are their but they do not erupt properly

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12
Q

What is the prognosis for a patient with cleidocranial dysplasia?

A

Good;

Live long life, often need extractions and orthodontics

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13
Q

___________ is a disorder often seen in children that causes painless bilateral expansion of the jaws, especially the mandible.

A

Cherubism

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14
Q

T/F: Surgical intervention is the best treatment for cherubism.

A

False

Can accelerate growth of lesions

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15
Q

T/F: Osteitis deformans (Paget disease) will cause weakening and thinning of bones.

A

False

Weakening and thickening

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16
Q

What are some clinical features of Paget’s disease?

A

40% have pain

“Simian” stance due to bowing of femurs

Elevated alkaline phosphatase

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17
Q

What is the radiographically appearance of bone in patients with osteitis deformans?

A

Cotton wool appearance

Hypercementosis

18
Q

What is the treatment for osteitis deformans?

A

No treatment if asymptomatic

Bisphosphonates

19
Q

What is the prognosis of osteitis deformans?

A

Not life-threatening

Watch for osteosarcoma

20
Q

What are some dental complications with patients with osteitis deformans?

A

Difficult to extract teeth, hemorrhage, and poor wound healing

Poor prognosis for implants

May need several dentures remade

21
Q

T/F: Fibrous dysplasia will present earlier in life than paget disease.

A

True

22
Q

T/F: The majority of fibrous dysplasia cases are polyostotic.

A

False

Monostotic (only involve one bone)

23
Q

What are the radiographic features of fibrous dysplasia?

A

Early stages radiolucent/mottled

Become opaque as they grow

“Ground glass” pattern

24
Q

What are the two types of polyostotic fibrous dysplasia?

A

Jaffe - two or more bones affected and cafe-au-lait spots with jagged border

McCune-Albright - 2 or more bones affected, cafe-au-lait spots and endocrine disturbances

25
Q

T/F: Fibrous dysplasia has a capsule.

A

False

Abnormal bone fuses to normal bone

26
Q

T/F: Regrowth is common after surgery for fibrous dysplasia.

A

True

25-50%

27
Q

What is the most common fibro-Osseous lesion encountered in dentistry?

A

Cemento-Osseous dysplasia

28
Q

What demographic most often gets cemento-Osseous dysplasia?

A

Black women

29
Q

T/F: Cemento-Osseous dysplasia will be seen around vital teeth.

A

True

30
Q

What is the most severe type of COD?

A

Florid Osseous dysplasia

*Periapical is most mild

31
Q

Which type of COD is more often seen in white females between 20-40 in the body of the mandible?

A

Focal COD

32
Q

What can focal COD often be confused with?

A

Ossifying fibroma

33
Q

What is an area of hematopoietic bone marrow of sufficient size to cause a radiographic radiolucency?

A

Osteoporotic bone marrow defect

34
Q

Where is the most likely place to see an osteoporotic bone marrow defect?

A

Posterior body of mandible at old extraction site

35
Q

T/F: Osteoporotic bone marrow defects involve abnormal osteoblastic activity.

A

False

No abnormal osteoblast/clast activity

36
Q

What is the most common site for idiopathic osteosclerosis?

A

Mandibular premolar/molar area

37
Q

Idiopathic osteosclerosis can be confused with….

A

Condensing osteitis, hypercementosis, cementoblastoma

38
Q

T/F: Simple bone cysts have an epithelial lining.

A

False

Not a true cyst

39
Q

What is a possible theory for etiology of simple bone cyst?

A

Trauma-hemorrhage theory

40
Q

What is a distinguishing radiographic feature of a simple bone cyst?

A

Scallops between roots

41
Q

What is the treatment for a simple bone cyst?

A

Surgical exploration -> causes bleeding -> organizes and heals lesion

AU18: Oral Path 2 (18 decks)

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