Salbutamol Flashcards
Presentation and dosage of salbutamol?
Nebules containing salbutamol 2.5 milligrams/2.5ml or 5 milligrams/2.5ml
Indications of Salbutamol?
Acute asthma attack where normal inhaler therapy has failed to relieve symptoms
Expiratory wheezing associated with allergy, anaphylaxis, smoke inhalation or other lower airway cause
Exacerbation of COPD
What is COPD?
chronic obstructive pulmonary disease
Actions of salbutamol?
Selective beta2 adrenoreceptor stimulant drug.
Has a relaxant effect on the smooth muscle medium in the smaller airways, which are in spasm in acute asthma attacks
If given by nebuliser, especially if oxygen powered, its smooth-muscle relaxing action, combined with the airway moistening effect of nebulisation, can relieve the attack rapidly
Contra-indications of Salbutamol?
None in the emergency situation
Cautions of Salbutamol?
Hypertension
Angina
Overactive thyroid
Late pregnancy (can relax uterus)
Severe hypertension may occur in patients on beta-blockers and half doses should be used unless there is profound hypertension
If COPD is a possibility limit nebulisation with oxygen to 6 minutes
Side effects of Salbutamol?
Tremor (Shaking) Tachycardia Palpitations Headache Feeling of tension Peripheral vasodilation Muscle cramps Rash
What is tachycardia?
Tachycardia is a condition that makes your heart beat more than 100 times per minute
What is Peripheral vasodilation?
Widening of your blood vessels in peripheral parts of your body such as your arms and legs
In acute severe or life-threatening asthma what should be given after the first dose of salbutamol?
Ipratropium
In acute asthma or COPD unresponsive to salbutamol alone, what can be given after salbutamol?
A single dose of Ipratropium
What precautions should be taken after initial relief from salbutamol administration?
Salbutamol provides initial relief
In more severe attacks, the use of steroids by injection or orally and further nebuliser therapy will be required
DO NOT be lulled into a false sense of security by an initial improvement after salbutamol nebulisation
What should be done regarding life threatening or acute severe asthma?
Undertake a time critical transfer to the nearest suitable receiving hospital
Provide nebulisation en-route
If COPD is a possibility what time should nebulisation with oxygen be limited too?
6 minutes
What may happen to children after significant doses of salbutamol, what should you do?
The pulse rate in children may exceed 140 after significant doses of salbutamol
This is not usually of any clinical significance and should not preclude further use of the drug