Chlorphenamine

Question 1

Drug code for Chlorphenamine?

Answer 1

CPH

Question 2

Presentation of Chlorphenamine?

Answer 2

Ampoule containing 10 milligrams of Chlorphenamine maleate in 1ml.
Tablet containing 4 milligrams of Chlorphenamine maleate
Oral solution containing 2 milligrams of Chlorphenamine maleate in 5 ml

Question 3

Indications for Chlorphenamine?

Answer 3

Severe anaphylactic after initial resuscitation.

Symptomatic allergic reactions falling short of anaphylaxis but causing patient distress e.g. severe itching

Question 4

Actions of Chlorphenamine?

Answer 4

An antihistamine with anticholinergic properties that blocks the effect of histamine released during a hypersensitivity (allergic) reaction

Question 5

Contra-indications of Chlorphenamine?

Answer 5

Known hypersensitivity
The anticholinergic properties of Chlorphenamine are intensified by monoamine oxidase inhibitors (MAOIs).
Chlorphenamine injection is therefore contraindicated in patients who have been treated with MAOIs within the last fourteen days

Question 6

Cautions of Chlorphenamine?

Answer 6

Pregnancy and breastfeeding 
Hypotension 
Epilepsy
Glaucoma
Severe liver disease

Question 7

What is Glaucoma?

Answer 7

a group of eye conditions that damage the optic nerve, the health of which is vital for good vision.

Question 8

What often causes glaucoma?

Answer 8

This damage is often caused by an abnormally high pressure in your eye.

Question 9

What is hypotension?

Answer 9

low blood pressure

Question 10

Side effects of Chlorphenamine?

Answer 10

Sedation
Dry mouth
Headache
Blurred vision 
Urinary retention 
Psychomotor impairment 
Gastrointestinal disturbance
Convulsions (rare)

Question 11

Who is more likely to suffer side effects of Chlorphenamine?

Answer 11

Children and older people are more likely to suffer side effects

Question 12

What must patients not do after receiving Chlorphenamine, why?

Answer 12

Warn anyone receiving Chlorphenamine against driving or undertaking any other complex psychomotor tasks, due to the sedative and psychomotor impairment side effects of Chlorphenamine

Question 13

What side effects can occur only when using intravenous preparation to administer Chlorphenamine?

Answer 13

transient hypotension
central nervous system (CNS) stimulation
irritant effects

Question 14

Dosage and administration of Chlorphenamine when using using the route of intravenous/intraosseous/intramuscular?

Answer 14

The IV route is the preferred route for anaphylaxis, given slowly over 1 minute
Small doses can be diluted with sodium chloride 0.9%

≥12 years 10 milligrams in 1ml
Initial dose: 10 milligrams 
Repeat dose: none 
Dose interval: N/A 
Volume: 1ml
Maximum dose: 10 milligrams

Question 15

Dosage and administration of Chlorphenamine when using the route of Oral, tablet?

Answer 15

≥12 years 4 milligrams per tablet
Initial dose: 4 milligrams 
Repeat dose: none 
Dose interval: N/A 
Volume: 1 tablet
Maximum dose: 4 milligrams

Question 16

Dosage and administration of Chlorphenamine when using the route of Oral, solution?

Answer 16

≥12 years 2 milligrams in 5ml 
Initial dose: 4 milligrams 
Repeat dose: none 
Dose interval: N/A 
Volume: 10ml
Maximum dose: 4 milligrams