Clopidogrel

Question 1

Drug code for clopidogrel?

Answer 1

CLO

Question 2

Presentation of clopidogrel?

Answer 2

Tablet, 75 milligrams or 300 milligrams

Question 3

Indications for clopidogrel?

Answer 3

Acute ST-elevation myocardial infarction (STEMI)
In patients not already taking clopidogrel
In patients receiving thrombolytic treatment
Anticipated thrombolytic treatment
Anticipated primary percutaneous coronary intervention (PPCI)

Question 4

Actions of clopidogrel?

Answer 4

Inhibits platelet aggregation

Question 5

Contra-indications of clopidogrel?

Answer 5

Known allergy or hypersensitivity to clopidogrel
Known severe liver impairment
Active pathological bleeding such as peptic ulcer or intracranial haemorrhage

Question 6

Cautions of clopidogrel?

Answer 6

As the likely benefits of a single dose of clopidogrel outweigh the potential risks, clopidogrel may be administered in…
Pregnancy
Patients taking non-steroidal anti-inflammatory drugs (NSAIDs)
Patients with renal impairment

Question 7

Side effects of clopidogrel?

Answer 7

Dyspepsia
Abdominal pain
Diarrhoea
Bleeding (Gastrointestinal and intracranial) - the occurrence of severe bleeding is similar to that observed with the administration of aspirin

Question 8

What is dyspepsia?

Answer 8

also known as indigestion, refers to discomfort or pain that occurs in the upper abdomen, often after eating or drinking.
It is not a disease but a symptom.

Question 9

Dosage and administration of clopidogrel?

Answer 9

Adults aged 18-75 years with acute ST-elevation myocardial infarction (STEMI) receiving thrombolysis or anticipated primary PCI, as per locally agreed STEMI care pathways

Question 10

What should clopidogrel be administered in conjunction with?

Answer 10

Aspirin

Unless there is a known aspirin allergy or sensitivity

Question 11

Route of administration for clopidogrel?

Answer 11

Oral

Question 12

Dosage and administration of clopidogrel during patient care pathway of thrombolysis?

Answer 12

Adult, 300 milligrams per tablet 
Initial dose: 300 milligrams
Repeat dose: None
Dose interval: N/A
Volume: 1 tablet
Maximum dose: 300 milligrams

Adult, 75 milligrams per tablet 
Initial dose: 300 milligrams
Repeat dose: None
Dose interval: N/A
Volume: 4 tablet
Maximum dose: 300 milligrams

Question 13

Dosage and administration of clopidogrel during patient care pathway of primary percutaneous coronary intervention?

Answer 13

Adult, 300 milligrams per tablet 
Initial dose: 600 milligrams
Repeat dose: None
Dose interval: N/A
Volume: 2 tablet
Maximum dose: 600 milligrams

Adult, 75 milligrams per tablet 
Initial dose: 600 milligrams
Repeat dose: None
Dose interval: N/A
Volume: 8 tablet
Maximum dose: 600 milligrams