S8 Special Circulations Flashcards
List 5 of the special circulations.
- Pulmonary
- Coronary
- Cerebral
- Skeletal
- Cutaneous
What are the two circulations in the lungs?
- bronchial circulation
* pulmonary circulation
What is the bronchial circulation?
- part of the systemic circulation
* meets the metabolic requirements of the lungs
What is the pulmonary circulation?
- supplies blood to the alveoli
* required for gas exchange
What must the pulmonary circulation accept the whole of?
Whole cardiac output
What is normal CO at rest? What is the maximum CO of a non-athlete?
- 5L/min
* 20-25L/min
Is the pulmonary circulation low or high pressure and resistance?
- low pressure
* low resistance
Why is diastole in the right ventricle the same/lower than diastole in the right atrium?
If it was higher than the right atrial diastolic pressure then blood wouldn’t flow as wouldn’t be down a concentration gradient
Why is the pressure in the atria only diastolic pressure?
The atria don’t undergo systole like the ventricles do
How is low resistance maintained in the pulmonary circulation?
- short, wide vessels
- lots of capillaries
- arterioles with little smooth muscle
What are the mean arterial, capillary and venous pressures in the pulmonary circulation?
Arterial - 12-15mmHg
Capillary - 9-12mmHg
Venous - 5mmHg
How is efficient gas exchange promotes in the pulmonary circulation?
- high density of capillaries in alveolar wall - large SA
- short diffusion distance
Means high oxygen and carbon dioxide transport capacity produced
What is the optimal ventilation-perfusion ratio (V/Q)?
0.8
What is needed for efficient oxygenation in terms of V/Q ratio? How is this maintained? When might this happen?
Need to match ventilation of alveoli with perfusion of alveoli
Maintained by diverting blood away from alveoli that aren’t well ventilated
Hypoxia
What is hypoxic pulmonary vasoconstriction?
Important mechanism in regulating pulmonary vascular tone.
When alveolar hypoxia occurs, vasoconstriction of pulmonary vessels occurs to ensure perfusion matches ventilation (poorly ventilated alveoli are less well perfumed) - to optimise gas exchange
This is the opposite to what happens in systemic circulation
What is a disadvantage of hypoxic vasoconstriction?
Can lead to right ventricular heart failure
- chronic hypoxia can occur at altitude or in diseases like hypoxia
- the chronic increase in vascular resistance leads to chronic pulmonary hypertension
- a high afterload on the right ventricle (due to pulmonary hypertension) leads to right ventricular heart failure
What are the low pressure pulmonary vessels strongly influenced by?
Gravity
How does gravity effect the pulmonary vessels?
In the upright position (orthostasis) there’s increase hydrostatic pressure on the blood vessels in the lower part of the lung
- at the apex - vessels collapse during diastole
- at the level of heart - vessels are continuously open
- at the base - vessels are ‘swollen’/distended
What is the effect of exercise on pulmonary blood flow?
- increases CO
- there’s a small increase in pulmonary arterial pressure
- this open apical capillaries (improves the V/Q ratio)
- there’s increased oxygen uptake by lungs
- as blood flow increases, capillary transit time decreases (can fall to 0.3s from 1s without compromising gas exchange)
How is tissue fluid formed?
Due to Starling forces
- hydrostatic pressure of blood in capillaries - pushes fluid out
- oncotic pressure - draws fluid in
In systemic circulation, does arterial or venous pressure influence capillary hydrostatic pressure more?
Venous pressure
How is lung lymph formation kept to a minimum?
Due to the low capillary pressure
Is oncotic pressure of tissue fluid higher in the lungs or periphery?
Lungs
Is capillary hydrostatic pressure higher in the lungs or systemic capillaries?
Systemic capillaries