S2 Control of Cardiac Output Flashcards

1
Q

What is afterload?

A

The load the heart must eject blood against e.g. the aortic pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the preload?

A

The amount the ventricles are stretched/filled in diastole (linked to EDV and central venous pressure (CVP))

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the total peripheral resistance?

A

Resistance to blood flow from all the systemic vasculature

Also known as systemic vascular resistance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What happens to pressure of fluid in a tube as it encounters resistance?

A

the pressure exerted drops as it flows through resistance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which blood vessels give the largest resistance? What does this increased resistance mean for capillaries, arterial side and the venous side?

A

Constriction of arterioles

Causes pressure decrease in capillaries and venous side and the pressure to increase in the arterial side - pressure builds up prior to resistance and less gets through past resistance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

If total peripheral resistance decreases and cardiac output stays the same, what happens to the arterial and venous pressures?

A
  • arterial pressure decreases - as cardiac output not increased
  • venous pressure increases
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What happens to arterial pressure and venous pressure if total peripheral resistance increases and cardiac output stays the same?

A
  • arterial pressure increases

* venous pressure decreases - blood can’t flow to venous side as easily

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

If cardiac output is increased and total peripheral resistance stays the same, what happens to the arterial and venous pressures?

A
  • arterial pressure increases - heart is pumping out more

* venous pressure decreases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

If cardiac output decreases and total peripheral resistance stays the same, what happens to the arterial and venous pressures?

A
  • arterial pressure decreases

* venous pressure increases (only a small increase)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How do you calculate cardiac output?

A

Stroke volume x heart rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How do you calculate stroke volume?

A

End diastolic volume - end systolic volume (SV = EDV - ESV)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How can you increase the stroke volume?

A

By increasing EDV or decreasing ESV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the stroke volume of a average 70kg man at rest?

A

About 70ml

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

When does the ventricle stop filling? What are the consequences for how much the heart fills and how high the pressure is?

What is this relationship called?

A

When the walls stretch enough to produce a intraventricular pressure equal to the venous pressure

The higher the venous pressure, the more the heart fills

And the more the heart fills, the higher the ventricular pressure

Ventricular compliance curve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

When can compliance be increased or decreased?

A

In diseased states

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the Frank-Starling Law of the heart?

A

(Like skeletal muscle) if you stretch the fibres of the heart before contracting, the contraction produced will be harder

The heart is stretched by increasing the amount the heart is filled

17
Q

An increased heart contraction means what for the stroke volume (increase of decrease)?

A

Increased stroke volume

18
Q

How does how much the ventricles fill and compliance relate?

A

How much the ventricles fills depends on the compliance

19
Q

What does increasing the venous return do to the left ventricular end diastolic/filling pressure? And ‘preload’ volume?

A

Increases the pressure

Increases the volume

20
Q

What is the normal sarcomere length?

What is the optimum sarcomere length?

A
  1. 9 micrometers

2. 2 micrometers

21
Q

What does a short sarcomere length mean for heart contraction?

A

If the sarcomere length is too shirt, filament overlap interferes with the contraction

22
Q

What ion do you get increased sensitivity to when muscle fibres are stretched?

A

Calcium ions

23
Q

What is an intrinsic control mechanism of the heart? Why is this a control mechanism?

A

Increasing stroke volume with increase filling of heart - it ensures both sides of heart maintain the same output

24
Q

What are the extrinsic control mechanism of the heart? Why are these mechanisms?

A

Sympathetic stimulation and circulating hormones e.g. adrenaline

They increase contractility

25
Q

What happens to the aortic/arterial pressure when peripheral resistance (TPR) is increased? What does this mean for the pumping?

What happens to the venous pressure in the same TPR situation?

A

Arterial/aortic pressure increases so harder to pump out blood due to reduced pressure gradient

Venous pressure decreases and so decrease in filling of the heart

26
Q

What two factors determine how much the ventricles empty (ESV)? And what are they determined by?

A
  1. How hard it contracts - determined by EDV and contractility
  2. How hard it is to eject blood - determined by aortic impedance/aortic pressure
27
Q

What is demand led pumping?

A

If metabolism increases, total peripheral resistance decreases so more blood can be supplied to tissues - decrease in arterial pressure, increase in venous pressure

The heart responds by pumping more

28
Q

What are contractility and heart rate controlled by?

A

The autonomic nervous system

29
Q

A decrease in blood pressure stimulates which part of the ANS?

A

The sympathetic nervous system

30
Q

How does the CVS respond after eating a meal?

A
  1. Reduced total peripheral resistance
  2. Decreased arterial pressure, increased venous pressure
  3. Increased heart rate and stroke volume
  4. Increased CO
  5. Increased arterial pressure, decreased venous pressure

A negative feedback loop

31
Q

How does the CVS respond to standing up?

A
  1. Reduced venous pressure
  2. Reduced CO
  3. Reduced arterial pressure
  4. Baroreceptor reflex and ANS increase heart rate and TPR
32
Q

Why do we need a CVS response to standing up?

A

Standing up causes ‘pooling’ of blood in legs due to gravity, if your reflexes don’t work, you get postural hypotension - feel dizzy

33
Q

What do baroreceptors detect? Where are they?

A

In the aortic arch

Detect changes in pressure

34
Q

How does the CVS respond to exercise?

A
  1. Increased venous pressure, heart rate and contractility (decreased TPR)
  2. Increased CO
35
Q

Why is there a fall in stroke volume as pressure increases on the Frank Starling curve?

A

Contraction has a limit

The sarcomere lengthens due to stretching and so actin and myosin filaments can no longer interact