S1 Haemodynamics Flashcards
What is serum?
Plasma without clotting factors
Is plasma viscosity or blood viscosity more common?
Plasma viscosity
What protein is present in plasma that is used as a clinical marker for inflammation?
CRP (c-reactive protein)
What is the movement of blood called?
Haemodynamics
What is laminar flow?
Smooth flow, maintains energy, silent, typical
What is turbulent flow?
Disorganised, noisy, energy is lost
Where is the lowest resistance in the blood vessel?
In the centre on the of the vessel
What is the critical Reynolds number?
The point when flow and perfusion pressure become mismatched
When does turbulent flow happen?
When pressure increase is beyond which the flow can match linearly
E.g. in stenosis in arteries (narrowing of arteries) flow is altered due to the artery being narrower
What units are flow and pressure measured in?
Flow - volume transferred per unit time (L/min)
Pressure - force per unit area (mmHg)
What equations related to haemodynamics do you need to know?
- pulse pressure (PP) = systolic blood pressure (SBP) - diastolic blood pressure (DBP)
- mean arterial pressure (MAP) = DBP + ((SBP - DBP)/3) = DBP + 1/3PP
- cardiac output (CO) = heart rate (HR) x stroke volume (SV)
- MAP = CO x total peripheral resistance (TPR)
What is conductance in haemodynamics?
Measure of the ease of flow
What is resistance in haemodynamics?
Measure of the difficulty of flow
What has to happen to change blood supply to an organ?
- resistance - biggest contributor to change in flow
* change in pressure
What happens to the pressure difference if resistance is increased and flow is maintained?
Pressure difference increases
How is flow related to resistance, inversely or directly?
Inversely
E.g. if resistance increases, flow decreases
What are primary factors in effecting resistance of flow?
- diameter - most important
- length of vessel
- viscosity
Are flow and radius inversely or directly related?
Directly (proportional)
E.g. radius decreases, flow decreases