S5 Autonomic Control of the CVS Flashcards
What is the sympathetic and parasympathetic effects on the pupil of the eye? What are the receptors?
Sympathetic - dilation (alpha 1)
Parasympathetic - contraction (muscarinic 3)
What is the sympathetic and parasympathetic effects on the airways of the lungs? What are the receptors?
Sympathetic - relax (beta 2)
Parasympathetic - contract (muscarinic 3)
What is the sympathetic and parasympathetic effects on the heart? What are the receptors?
Sympathetic - increase rate and force of contraction (beta 1)
Parasympathetic - decreases rate (muscarinic 2)
What is the sympathetic effects on the sweat glands? What are the receptors?
Localised secretion (alpha 1) Generalised secretion (muscarinic 3)
What does the autonomic nervous system exert control over?
- smooth muscle
- exocrine secretion
- rate and force of contraction in the heart
What does the ANS control in the cardiovascular system?
- heart rate
- force of contraction of heart
- peripheral resistance of blood vessels
What doesn’t the ANS do in the cardiovascular system?
Doesn’t initiate electrical activity in the heart
What happens if you denervate the heart?
It will still beat but at a faster rate (under influence of the vagus (X) nerve)
What neurotransmitter does parasympathetic postganglionic cells release
ACh
What receptors does the ACh act on (in the parasympathetic input to the heart)?
M2-receptors
What does ACh binding to M2-receptors in the heart cause?
- decreases heart rate (negative chronological effect)
* decrease in AV node conduction velocity
Where do the preganglionic fibres of the parasympathetic nervous system come from?
The 10th cranial nerve - vagus nerve
Where do the postganglionic fibres of the sympathetic nervous system come from?
The sympathetic trunk
What does the sympathetic nervous system innervates in the heart?
- SA node
- AV node
- myocardium
What does the sympathetic postganglionic fibres release?
Noradrenaline
What receptors does the noradrenaline act on (in the sympathetic input to the heart)?
Beta-1 adrenoreceptors
What does noradrenaline binding to beta-1 adrenoreceptors in the heart cause?
- increases heart rate (positive chronotropic effect)
* increases force of contraction (positive inotropic effect)
What is the pacemaker of the heart?
Cells in the sinoatrial node (SA node) steadily depolarise towards the threshold (pacemaker potential) results in turning on of a slow Na+ conductance (funny current) and Ca2+ channels open
Action potential firing in the SA node sets the rhythm of the heart