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MSII: Pathology Unit 6 > Rubin's Pancreas > Flashcards

Rubin's Pancreas Flashcards

1
Q

describe embriology of the pancreas?

A

ventral and dorsal pancreas join to make the pancreatic duct of Wirsung

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2
Q

describe acinar cells?

A

zymogen granules

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3
Q

“failure of 2 ambryonic pancreatic ducts to fuse”

A

pancreatic divisim

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4
Q

Most common pancreatic congenital anomaly?

A

pancreatic divism

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5
Q

“pancreatic tissue occuring outside its normal location with abundent smooth muscle”

A

heterotropic pancreas

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6
Q

“developmental malformation in which the pancreas forms a ring around the duodenum”

A

annular pancreas

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7
Q

“homozygous mutation of heomeodomain transcription factor IPF1”

A

partial or complete pancreatic agenesis

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8
Q

“inflammation and hemorrhage of the pancreas”

A

acute pancreatitis

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9
Q

What causes acute pancreatitis?

A

release of pancreatic digestive enzymes (premature activation of trypson leads to activation of other pancreatic enzymes

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10
Q

What are the histologic findings of acute pancreatitis?

A

Patchy acinar cell and fat necrosis and a little inflammation

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11
Q

Two major risk factors for acute pancreatitis?

A

1- Gallstones

2- chornic alcohol consumption

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12
Q

Name 2 serum markers for acute pancreatitis?

A

Increased serum lipase and amylase

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13
Q

Name 5 complications of acute pancreatitis?

A 
1- shock
2- pancreatic psuedocyst
3- pancreatic abscess
4- DIC
5- ARDS
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14
Q

“CT lined pocket that forms following acute pancreatitis–> surrounds liquifactive necrosis and pancreatic enzymes”

A

pancreatic pseudocyst

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15
Q

“fibrosis of pancreatic parenchyma due to progressive destruction”

A

chronic pancreatitis

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16
Q

Major adult and chilhood causes of chronic pancreatitis??

A

Adult–> alcohol

Child–> CF

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17
Q

Findings in CF generated chronic pancreatitis?

A

Mucous plugs

18
Q

Findings in alcohol generated chronic pancreatitis?

A

Protein plugs from hypersecretion of enzymes

19
Q

Most common pathological type of chronic pancreatitis?

A

chronic calcifying pancreatitis

20
Q

Name 4 complications of chronic pancreatitis?

A

1- pancreatic insufficiency (malabsorbion and vit ADEK deficiency)

2- dystrophic calcification of pancreatic parenchyma

3- secondary T2DM

4- pancreatic carcinoma

21
Q

“point mutations that increase trypsinogen and trypsin levels”

A

Hereditary pancreatitis

22
Q

Most common adult pancreatic tumor?

A

Infiltrating ductal adenocarcinomas

23
Q

Typical age of pancreatic cancer?

A

70yo

24
Q

“preneoplastic ductal proliferation characterized by replacement of ductal epithelium with mucous epithelium”

A

Pancreatic intraductal neoplasia

25
Q

2 major risk factors for pancreatic carcinoma?

A

smoking and chronic pancreatitis

26
Q

Most common location of pancreatic carcinoma?

A

head of the pancreas

27
Q

2 “signs” of pancreatic cancer?

A

Trousseau syndrome–> mgratory thrombophlebitis

Courvoisier sign–> acute painless gallbladder dilation and jaundice

28
Q

Symptoms of migratory thrombophlebitis?

A

swelling, erythema and tenderness in extremites

29
Q

“tumor cells that look nd acit like normal acinar cells and produce exocrine enxymes”

A

acinar cell carcinoma

30
Q

Paraneoplastic syndromes of acinar cell carcinoma?

A

fat necrosis, polyarthralgia and peripheral eosinophelia

31
Q

“pancreatic tumor of childhood associated withBeck Wideman syndrome”

A

Pancreatoblastoma

32
Q

Serum marker for pancreatoblastoma?

A

alpha FP

33
Q

“pancreatic tumor lined by glycogen risk cuboidal epithelium”

A

serous cystic neoplasm

34
Q

“dilated pancreatic ducts lined by neoplastic mucinous epithelium and filled with mucous”

A

intraductal papillary mucinous neoplasm

35
Q

“cystic neoplasm lined by mucous secreting epithelium with underlying cellular, ovarian type stroma”

A

mucinous cystic neoplasm

36
Q

“tumor in girls and young women associated with degnerated areas filled with blood and necrotic debris”

A

solid psuedopapillary neoplasm

37
Q

Endocrine pancreatic tumor that is associated with MEN1?

A

pancreatic gastrinoma

38
Q

Syndrome associated with gastrinoma?

A

Zollinger - Ellison Syndrome

39
Q

Symptoms of insulinoma?

A

hypoglycemia (confusion, blurred vision, sweathing, palpitations)

40
Q

Symptoms of glucogonoma?

A

anemia, diabetes, necrolytic migratry erythema

41
Q

Symptoms of somatostainoma?

A

cholelithiasis, diabetes, steatorrhea

42
Q

Symptoms of VIPoma?

A

achlorhydria, severe diarrhea

MSII: Pathology Unit 6 (12 decks)

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