Rubella Virus

Question 1

Virology of Rubella
Is the virus enveloped or unenveloped?
Is the virus RNA or DNA ?
what are the parts of a rubella virus?

Answer 1

Rubella virus is enveloped
Rubella is ssRNA (pos sense)
Lipid bilayer,capsid, envelope and RNA

Question 2

Virology: Rubella
what type of family does Rubella belong to ?
cellular mechanism on how rubella infect cells

Answer 2

Toga family
rubella infects cells via receptor mediated endocytosis

The positive -sense RNA is translated to produce viral proteins; including RNA-dependent RNA polymerase

Question 3

Transmission:
1. reservoir of rubella
2. how is it transmitted
3. can an infected pregnant woman tranfer the virus to the fetus ?
4. how is it transmitable from mother to child ?

Answer 3

1. humans
2. respiratory droplets
3. yes
4. through viremia (virus in blood)

Question 4

Prodromal period of rubella express and shows sxs and signs of:

Answer 4

fever
enlarged lymphnodes (7 days before rash shows up)
rash
sore throat

Question 5

Manifestations of Rubella mostly in women

Answer 5

Arthritis

Question 6

Pathogenesis:
In acquired infection how does the virus enter ?

Answer 6

in the upper respiratory system

Question 7

Rubella despite of high infectivity it does have low ?

Answer 7

virulence

Question 8

Traits of Rubella rash

Answer 8

maculopapular
3 day rash
can be identified individually vs base measles
petechial red spots in palate and throat

Lesions of rubella can involve multiple systems

Question 9

1. Immunity: Immunoglobulins (antibody)
2. After infection of rubella which antibody titers rise ?
3. reaching a peak of how long ?
   Natural infection produces what type of antibody ?
4. Reinfection can lead to respiratory infection, with anamnestic rise in what antibody ?
5. While reinfection with the high rise in IgG what type of antibody is spontanously secreted?

Answer 9

1. IgM and IgG antibodies
   2.2 to 3 weeks of onset
2. IgA in the respiratory tract
3. IgG
4. IgA

Note: :asting immunity is associated with IgG and IgA

Question 10

explain why child bearing woman are a concern in regards to rubella ?

Answer 10

Because if the woman is infected it can transmit the disease to the fetus, and can cause massive destruction, defects and malformation to the fetus

Question 11

In which trimester of a womans pregnancy is cruicial to infecting the fetus ?

Answer 11

first trimester
forst 2 weeks gestation

Question 12

Congenital Rubela Syndrome

Answer 12

fetal infection can be chronic
congenital abnormalities
malformation (organogenesis disruption)
sensory
cardiac
microcephaly (small head)
autism

Question 13

what type of antibody can detect congenital infections

Answer 13

via IgM

Question 14

Vaccines
Recomended vac for children and healthcare workers?
vaccine is contra indicated to

Answer 14

MMRV Live (attenuated)
immunocompromised people and in pregnancy

non pregnant child-bearing stage women should avoid conception 3 mos after receiving the vaccine.

Question 15

In the lab where can rubella grow ?

Answer 15

Diploid fibroblast cell cultures