Rotenone

Question 1

What is rotenone?

Answer 1

Rotenoid plant extract

Odorless and COLORLESS crystalline ketonic chemical

Question 2

Give a few qualities about the metabolism and exposure of rotenone.

Answer 2

Readily degraded upon exposure to warm air and light
More lipophilic than hydrophilic
Inhalation is more toxic
Metabolized in liver - excreted in urine and feces within 24 hrs

Question 3

What species is rotenone most neurotoxic to?

Answer 3

Fish and Arthropods

Question 4

What is the MOA of rotenone?

Answer 4

Blocks oxidative phosphorylation in the TCA cycle

Question 5

What are some of the clinical signs of rotenone?

Answer 5

DEPRESSION AND CONVULSIONS are the predominate CS+ with a neurotoxin
Conjunctivitis, muscle tremors, lethargy, respiratory stimulation followed by depression, liver changes, pulmonary irritation, and asphyxia, GI tract irritant

Question 6

What are some abnormalities found in the labs?

Answer 6

Antemortem- hypoglycemia, liver enzyme changes, hypoxemia/hypercapnea

Question 7

How do you diagnose rotenone toxicosis?

Answer 7

Based on Hx and documentation of exposure

Question 8

What is the treatment?

Answer 8

No specific treatment

Question 9

What is the prognosis?

Answer 9

Good for birds and mammals

Fish, reptiles, amphibians, insects- poor prognosis