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RUSVM Toxicology > Neonicotinoids > Flashcards

Neonicotinoids Flashcards

1
Q

What is the most widely used insecticides in the world?

A

Imidacloprid (Neonicotinoid)

-25% of all insecticide use

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2
Q

What is the MOA of neonicotinoids?

A

Bind to nicotinic receptors for the NT Ach in the insect CNS

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3
Q

What are some of the properties of neonicotinoids?

A

Water soluble
Degrades slowly in environment
Degraded by direct light (half-life approx 34 days)
CHARGED NITROGEN METABOLITES (TOXIC TO NON-TARGETED SPECIES)

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4
Q

What are some of the toxicokinetics of neonicotinoids?

A

Poorly absorbed
Metabolized in liver
Excreted in bile and urine

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5
Q

What is the MOA of neonicotinoids?

A

Neonicotinoids bind acheylcholinesterase - BINDING IS IRREVERSIBLE (OP!)
Neonicotinoids are acetylcholine receptor agonists- binds to nicotinic receptors

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6
Q

What species have relatively low toxicity to neonicotinoids?

A

Mammals and birds

Cannot cross the BBB in mammals, but can in insects

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7
Q

What are the clinical sings for neonicotinoids?

A

Similar to that for nicotine toxicity

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RUSVM Toxicology (23 decks)

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