Role Of GIT In Drug Absorption Flashcards
The factors that influence the rate and extent of absorption depend upon what
Route of administration
Factors affecting the absorption will depend on the what
Define oral drug absorption
Define the rate limiting step
The rate limiting steps could be what
Explain the physiology of the gastrointestinal tract
Explain the esophagus
Explain the two main function of the stomach
Why little drug absorption in the stomach
Small surface area
Acidic media
Gastric emptying
Limited blood supply
What is the main function of small intestine
What are the main reasons why the small intestine is the main site for absorption
Large surface area
Long residency
Blood supply
What are the main functions of the colon
Why is absorption limited in the colon
Small surface area
Limited blood supply
Define gastric emptying
What is the normal gastric residence time
What are the factors influencing the gastric emptying
Explain the small intestinal transit
Small intestinal transit is important for what
Explain colonic transition
What are the two types of contractile activity in the colon
Propulsive and segmental contractions
Explain propulsive contractions
Explain segmental contractions
What is the total transit times
