Absorption From Different Sites Of Administration Part 2 Flashcards
Nasal drug delivery used for…
Local or systemic effects
Why is nasal drug delivery useful for systemic drug delivery
Because the nasal region is richly supplied with blood vessels
What are the factors that limit the the noses capacity for systemic delivery of drugs requiring large doses
To be absorbed by nasal route the drug should be what
Lipophilic to cross the membranes of the nasal epithelium
What are the factors affecting drug absorption after nasal administration
Why nasal drug delivery is promising
What are the challenges of nasal drug delivery
What is absorbed more easily in the nasal drug delivery
Small molecules with balanced lipophilic and hydrophilic properties
What is not absorbed through nasal drug delivery
What are the dosage forms for nasal drug delivery
Nasal drops
Nasal sprays
Aerosols
Nebulizers
What is the objective of nasal drug delivery
Inhalation drug delivery could be used for…
Local or systemic drug effects
What is the benefit of inhalation drug delivery over nasal passage and small intestine
Explain inhalation drug delivery
What are the factors affecting drug absorption through inhalation
Particle size
Administered dose
Explain particle size as the factor affecting the absorption of inhalation drug delivery
What’s the percentage of the administered drug that reaches the respiratory tract
10%
Explain sublingual administration
Give example of sublingual administration
What are the dosage forms used in sublingual administration
