Absorption From Different Sites Of Administration Flashcards
Three primary routes of parenteral administration
Subcutaneous
Intramuscular
Intravenous
When is parenteral route preferred
What is the benefit of parenteral route over oral
What is the only route where there is no factors affecting it
Intravenous injection
Explain intravenous injections
In intravenous injection drugs may be administered how
Intravenous injection allows what
What is the site of intramuscular injection
Deep into skeletal muscle
What are the different dosage forms for intramuscular injection
What is the benefit of IM over SC
In IM absorption can be modulated by what
Local heating
Massage
Exercise
In IM where is the absorption of aqueous preparation faster
What are the factors affecting IM
Explain how gender affects rate of absorption in IM
When is there slow constant absorption from the intramuscular,jar site
If the drug is injected in solution in oil or suspended in various other depot vehicles
Explain low solubility in IM
Give example for IM injection that is long acting
How is SC injection administered
Injection through the skin into the loose subcutaneous tissue
What happens after subcutaneous injection
The drug comes into the surrounding area of blood capillaries and permeates them by diffusion or filtration
Explain capillary wall
Explain lipid-insoluble drugs penetration
Which membrane is crossed more rapidly by all substances
Capillary membrane
What are the factors affecting SC injections
Site of injection
Surface area
Drugs
Physical exercise
Explain site of injection and surface area as factors affecting SC injection
What are the drugs that could affect SC injection
Vasoconstrictors and vasodilators
How do vasoconstrictors affect SC injection
When is vasoconstrictors used beneficially
How do vasodilators affect SC injection
How does physical exercise affect SC injection give example
