Mechanisms Of Transport 2 Flashcards
Explain passive diffusion
In passive diffusion the rate of transport is determined by what
Physiochemical properties of the drug
the nature of the membrane
Concentration of the drug across the membrane
Explain the process of passive diffusion
What happens to the drug in passive diffusion upon reaching the blood
Passive diffusion is described by what
The rate of diffusion of a drug across the membrane depends on what
Majority of drugs are absorbed how
Across the cells via passive diffusion
Carrier mediated absorption is often explained by assuming what
Shuttling process across the epithelial membrane
Explain how drug is absorbed via carrier mediated transport
What happens to the carrier after the drug is absorbed
Types of carrier mediated transport
Explain active transport
From where does energy arise for active transport
Hydrolysis of ATP
Transmembranous sodium gradient and/or electrical potential
What are the nutrients that are actively transported
Explain the specificity of carriers in active transport
Explain the difference between rate absorptions in passive absorption and active transport
Important points of the active transport mechanisms
Active transport also plays an important role in what
Intestinal, renal and biliary excretion of many drugs
What is the difference between active transport and facilitated diffusion
Explain facilitated diffusion
Explain the process of endocytosis
What happens after invagination in endocytosis
Does endocytosis require energy
Yes
What are the types of endocytosis
Endocytosis is the primary mechanism of transport of what
Macromolecules
Explain pinocytosis
Explain receptor-mediated endocytosis
Explain phagocytosis
What are the several drugs that are transported into cells via endocytosis
Explain paracellular transport
Paracellular route of absorption is important when
