RoA - Tablets/oral route

Question 1

Advantages of tablets

Answer 1

Convenient to take/handle
Longer shelf life (more stable than liquid)
Precise dosing of drug
Relatively cheap

Question 2

Disadvantage of tablets

Answer 2

Port drug bioavailability (solubility, absorption, instable in GIT)
May cause local irritation
May cause GI mucosa damage

Question 3

Tablet excipients - Filler

Answer 3

Increase bulk volume/size

Eg lactose

Question 4

Tablet excipients - disintegrant

Answer 4

Let’s table break with liquid
Promotes quick dissolution plus bioavailability
Eg: starch

Question 5

Tablet excipients - binder (adhesive)

Answer 5

Let’s granules tablets to form with required mechanical strength
Eg: starch

Question 6

Tablet excipients - glidant

Answer 6

Improve powder flowability
Eg: colloidal silica
(Particles small, reduce inter particulate friction)

Question 7

Tablet excipients - lubricant

Answer 7

Decreases friction between ingredients

Eg: magnesium stearate

Question 8

Tablet excipients - anti-adherant

Answer 8

Prevents sticking to punch

Eg: starch

Question 9

Disintegrating tablets?

Answer 9

Release drug quickly

Question 10

Castro-resistant tablets

Answer 10

Delayed release into intestinal fluid

Gastro resistant coating

Question 11

Modified-release tablet

Answer 11

Prolonged release (slowly)
Delayed release - some time after admin
Pulsatile - drug released in 2 or more pulses

Question 12

Dispersive tablets

Answer 12

In water before admin

Question 13

Crodispersible tablets

Answer 13

Disperse in mouth

Question 14

Soluble tablets

Answer 14

In water before admin

Question 15

Effervescent tablets

Answer 15

In water before admin

Fast drug absorption/minimise stomach irritation

Question 16

Lozenges

Answer 16

Hard (local affect)

Question 17

Pastilles

Answer 17

Soft (local affect)

Question 18

Single punch press

Answer 18

One punch one die

Question 19

Rotator presses (multi-station)

Answer 19

Multiple sets of punches and dies which rotate together

Question 20

Tablet formation

Answer 20

Powder fills die
Upper punch compresses powder
Lower punch rises to eject tablet and punch from die

Question 21

Advantages of oral route

Answer 21

Most common (60%)
Simplest, safe, convenient
Modified release formulation available (Eg:gastro resistant)
High SA = good absorption

Question 22

Oral disadvantages

Answer 22

Slower onset of action (dissolution)
Variable absorption (age,gender,disease)
Hostile environment (pH, enzymes, GIT)
First pass metabolism 
Difficult to reverse therapy 
GI irritation

Question 23

Sublingual tablets?

Answer 23

Placed under the tongue

Question 24

Buccaneers tablets

Answer 24

Placed in buffalo cavity between cheek and gum

Question 25

What is good about sublingual and bucks RoA?

Answer 25

Provide rapid drug release for systemic effect and avoid first pass metabolism