RoA - Inhaled Flashcards
1
Q
Inhaled advantages
A
Smaller doses can be used to produce effect Decreases systemic effects Rapid absorption so fast onset of action Avoids GI upset Avoids 1st pass metabolism Avoids harsh GI
2
Q
Inhaled disadvantages
A
Drug absorption low due to mucus layer
Requires complex delivery device - high cost
Aerosol device can be difficult to use
reproducibility low due to breathing pattern
Airways deposition can lead to local side effects
3
Q
Where does gravitational sedimentation take place?
A
Small airways/alveoli
Particle size/density affects
4
Q
Patient factors affecting deposition
A
Lung physiology (capacity)
Breathing pattern
Presence of pulmonary disease
5
Q
When does drug absorption take place
A
When dissolution is faster than clearance
