RoA - Capsules Flashcards
Capsule advantages
Easy to swallow Easy to handle/carry Mask taste/smell of drugs Minimal expedients needed Easy to identify (colour)
Capsule disadvantages
Not suitable for highly soluble substances (KCl) can lead to sudden release in stomach
Not suitable for dry materials
Costs more than tablets
Hard capsule - filling
Exact dose placed on surface of body plate and filled with spatula then locked (2 piece)
Advantages of soft capsules
Better drug absorption (in solution already)
Enhanced safety (no airborne powders)
Product stable against moisture/oxidation
What material used for capsule shell?
Gelatin - prepared by hydrolysis of collagen from connective tissues
Properties of gelatin
Non toxic/irritant
Soluble in biological fluids
Produces strong flexible film
(-ve:allergies/religious)
Excipients - dilvents
Bulk forming properties
Excipients - lubricants
Reduce powder to meal adhesion
Excipients - glidant
Reduce powder cohesion
Excipients - wetting agent
Improve water penetration
Excipients - stabilisers
Improve product stability
Excipients - disintegrants
Produce disruption of powder mass
