+/- RNA viruses - AuCoin Flashcards
Describe the genome of reo virus?
segmented dsRNA
how is reovirus transmitted?
fecal oral route
What is the most common cause of severe diarrhea in INFANTS?
REOVIRUS
Where does reovirus replicate?
mucosal cells of the small intestine
where is the specific strain of reovirus that is infectious?
rotavirus
T/f: rotavirus diarrhea is bloody
false
HOw do you diagnose rotavirus?
clinical, can use ELISA on stool samples
what is the Tx for rotavirus?
oral rehydration therapy to replace lost electrolytes
What are the two vaccines available for rotavirus?
Rotarix and Rota Teq
T/f: the +RNA strand of dsRNA is directly translated into protein
false
Describe the process of producing mRNA from dsRNA?
genomic -RNA is made into mRNA (+sense)
T/F: dsRNA must have a physical RNA dep RNA pol wihtin the capsid to be infectious
true
does the segmented RNA genome of rotavirus code for polyproteins or for one-protein-one gene?
one protein one gene
What is unique about the post translational mod of the rotaviral mRNA?
it is capped but lacks a poly A tail
What cellular structure is required for rotaviral uncoating?
low pH of the lysosome
where in the world are deaths from rotavirus common?
afrika
what do both of the rotavirus vaccines contain?
live attenuated virus
Human T-lymphotropic virus is an oncovirus associated with (blank)
adult T-cell leukemia
What cell does HTLV infect?
CD4+ T cells
How is HTLV transmitted?
in semen, blood, and breast milk
ATL has a loooooong incubation period of:
20-50 years
What are the hallmarks of ATL?
increased skin lesions, leukemia cells, hepatosplenomegaly, and hypercalcemia
How do you diagnose HTLV?
ELISA serology
Is there a vaccine for HTLV?
No, or we would have a cure for cancer!!
In HIV, (blank) binds the CD4 receptor
gp120
to what cells does gp120 bind?
T cells, monocytes, and dendritic cells
What are the ways that HIV is transmitted?
sex, blood, IVDU, and vertically
What word do we use to describe the types of infections that HIV patients get?
opportunistic
The acute phase of HIV infection has what types of symptoms?
flu like
latent HIV infection has what symptoms?
weight loss, night sweats, fatigue, lymphadenopathy
How long does it take for HIV to go to AIDS?
10 years
What is the threshold for AIDS diagnosis?
less than 200 T cells/ml
How do you diagnose HIV?
serology, then RT PCR to determine viral load
Oral thrush could be a sign in context that a patient has?
HIV
