DNA NON-enveloped viruses - Verma

Question 1

pharyngitis, common cold, pneumonia, and conjunctivitis are all caused by what family of virus?

Answer 1

Adenovirus

Question 2

Pharygno-conjunctival fever is what number of adenovirus?

Answer 2

adenovirus 3 and 7

Question 3

Pneumonias and common cold- all ages
conjunctivitis (pink eye)-all ages
Acute respiratory disease (types 4 and 7)-all ages
Kerato-conjunctivitis (types 8, 19 and 37)-adults
Acute gastroenteritis (types 40 and 41)-infants and young children

these are all caused by:

Answer 3

adenovirus

Question 4

what cells does adenovirus infect?

Answer 4

epithelial cells lining oropharynx, resp and GI tract

Question 5

Does the adenovirus infection itself or host defenses cause cytotoxic damage?

Answer 5

virus itself

Question 6

what is the mode of transmission of adenovirus?

Answer 6

aerosol, close contact or fecal oral

Question 7

(blank) from the host is important in resolving the infection

Answer 7

abs

Question 8

(blank) spreads adenoviral spread (CDC campaigns for it all the time)

Answer 8

hand washing

Question 9

Is there antiviral therapy for adenovirus?

Answer 9

no, or we would have the cure for the common cold

Question 10

How do you Dx adenovirus?

Answer 10

culturing, serology for Ag, and PCR

Question 11

If you have a negative strep, cervical adenopathy, conjunctivitis, and sore throat, what do you suspect?

Answer 11

adenovirus

Question 12

Papillomas are benign tumors of (blank) cells

Answer 12

squamous

Question 13

HPV types (blank and blankk) cause carcinoma of cervix, penis, and anus

Answer 13

16 and 18

Question 14

what two proteins from HPV are the cause of cancer?

Answer 14

E7 and E6

Question 15

What two tumor suppressor genes are inactivated by E6/7 in HPV?

Answer 15

p53 and pRB

Question 16

Skin and plantar warts are caused by what numbers of HPV?

Answer 16

1-4

Question 17

Anogenital warts (not cancer) are caused by what numbers of HPV?

Answer 17

6 and 11

Question 18

Laryngeal papilloma in young children is an HPV infection presenting as:

Answer 18

benign head and neck tumors

Question 19

T/F: HPV is easily inactivated

Answer 19

false

Question 20

What is the scary easy way that HPV can be spread? And the other ways?

Answer 20

BREAKS IN THE SKIN; sex, vertically

Question 21

what is the most common STI in the world?

Answer 21

HPV

Question 22

HPV is present in what percent of all cervical cancer?

Answer 22

99.7%

Question 23

Which strains of HPV are high risk?

Answer 23

16, 18, 31, 45

Question 24

Which strains of HPV are low risk?

Answer 24

6 and 11

Question 25

T/F: HPV infects mucosal cells

Answer 25

true; CONJUNCTIVAL papilloma, genital and oral papilomas

Question 26

E6/7 are (blank)genes

Answer 26

oncogenes

Question 27

How do we Dx HPV?

Answer 27

microscopic exam; PCR

Question 28

What are the treatments for HPV?

Answer 28

Podophylin, IFN, and cidofovir

Question 29

Liquid nitrogen is used to treat (blank) warts. Surgical removal or use of (blank) acid is also used

Answer 29

skin warts; salicylic acid

Question 30

Gardasil vaccine protects against which strains?

Answer 30

6, 11, 16, 18

Question 31

Cervarix vaccine protects against which strains?

Answer 31

16 and 18 only

Question 32

Even though an HPV infection (warts) may resolve in its own, the viral infection goes (blank)

Answer 32

latent

Question 33

What is the topical interferon used to treat HPV genital warts?

Answer 33

Imiquimod

Question 34

What is unique about the Parvovirus genome?

Answer 34

ssDNA

Question 35

What causes slapped cheek syndrome aka 5th disease? what is the medical name for this disease?

Answer 35

Erythema infectiosum; caused by parvovirus

Question 36

What are the other four rashes that gives 5th disease it's name?

Answer 36

Measles, rubella, scarlet fever, and roseola

Question 37

what is the mode of transmission of parvovirus?

Answer 37

resp inhalation

Question 38

JC virus and BK virus are two types of (blank) viruses that infect humans

Answer 38

polyomavirus

Question 39

T/F: the monkey SV40 polyoma virus can infect humans as well

Answer 39

true

Question 40

T/F: polyomavirus genome is only 5kb in size

Answer 40

true

Question 41

Progressive multifocal leukoencephalopathy is what?

Answer 41

fatal demyelinating disease of white matter involving multiple areas of the brain

Question 42

Progressive multifocal leukoenceophalopathy is seen in what type of infection?

Answer 42

polyoma virus

Question 43

What affects the visual field and causes weakness, leading to blindness and dementia and death within six months?

Answer 43

PML

Question 44

IN what group of patients do we see PML?

Answer 44

AIDS pts

Question 45

(JC/BK) virus can cause nephropathy and graft loss in immune suppresed renal transplant patients

Answer 45

BK virus

Question 46

In what percent of people do we find Abs for JC virus?

Answer 46

75%

Question 47

T/F: BK virus is also widepsread

Answer 47

true

Question 48

When is polyomavirus reactivated?

Answer 48

when there is immune compromise

Question 49

Where does polyomavirus persist?

Answer 49

Kidney cells, excreted in the urine

Question 50

From what fluid can you do PCR to diagnose polyomavirus?

Answer 50

CSF

Question 51

Is there treatment for polyomavirus?

Answer 51

nope

Question 52

By what mode of transmission is JCV spread that allows it to reach such high prevalence?

Answer 52

respiratory

Question 53

JCV goes latent in kidneys, (blanks and blanks)

Answer 53

lungs and lymphoid organs

Question 54

What are the earliest signs of PML?

Answer 54

speech and vision abnormalities

Question 55

Kuru is caused by what?

Answer 55

prions; eating human brains

Question 56

What are the infectious materials that allow the spread of Creutzfeldt Jacob disease?

Answer 56

corneal transplant, brain electrodes, and growth hormone

Question 57

What are the three ways of getting CJD?

Answer 57

1. Iatrogenic infection 2. Hereditary 3. Spontaneous mutation

Question 58

prions cause what category of illness?

Answer 58

transmissable spongiform encephalitis

Question 59

Scrapie is a (blank) mediated spongiform encephalopathy

Answer 59

prion

Question 60

When does CJD normally onset?

Answer 60

50-70 years

Question 61

What is the most common cause of CJD?

Answer 61

sporadic, over 85%

Question 62

Ingestion of beef infected with BSE prions will lead to what disease?

Answer 62

CJD