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Block 6 Week 4 Colt > DNA NON-enveloped viruses - Verma > Flashcards

DNA NON-enveloped viruses - Verma Flashcards

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1
Q

pharyngitis, common cold, pneumonia, and conjunctivitis are all caused by what family of virus?

A

Adenovirus

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2
Q

Pharygno-conjunctival fever is what number of adenovirus?

A

adenovirus 3 and 7

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3
Q

Pneumonias and common cold- all ages
conjunctivitis (pink eye)-all ages
Acute respiratory disease (types 4 and 7)-all ages
Kerato-conjunctivitis (types 8, 19 and 37)-adults
Acute gastroenteritis (types 40 and 41)-infants and young children

these are all caused by:

A

adenovirus

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4
Q

what cells does adenovirus infect?

A

epithelial cells lining oropharynx, resp and GI tract

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5
Q

Does the adenovirus infection itself or host defenses cause cytotoxic damage?

A

virus itself

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6
Q

what is the mode of transmission of adenovirus?

A

aerosol, close contact or fecal oral

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7
Q

(blank) from the host is important in resolving the infection

A

abs

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8
Q

(blank) spreads adenoviral spread (CDC campaigns for it all the time)

A

hand washing

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9
Q

Is there antiviral therapy for adenovirus?

A

no, or we would have the cure for the common cold

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10
Q

How do you Dx adenovirus?

A

culturing, serology for Ag, and PCR

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11
Q

If you have a negative strep, cervical adenopathy, conjunctivitis, and sore throat, what do you suspect?

A

adenovirus

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12
Q

Papillomas are benign tumors of (blank) cells

A

squamous

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13
Q

HPV types (blank and blankk) cause carcinoma of cervix, penis, and anus

A

16 and 18

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14
Q

what two proteins from HPV are the cause of cancer?

A

E7 and E6

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15
Q

What two tumor suppressor genes are inactivated by E6/7 in HPV?

A

p53 and pRB

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16
Q

Skin and plantar warts are caused by what numbers of HPV?

A

1-4

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17
Q

Anogenital warts (not cancer) are caused by what numbers of HPV?

A

6 and 11

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18
Q

Laryngeal papilloma in young children is an HPV infection presenting as:

A

benign head and neck tumors

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19
Q

T/F: HPV is easily inactivated

A

false

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20
Q

What is the scary easy way that HPV can be spread? And the other ways?

A

BREAKS IN THE SKIN; sex, vertically

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21
Q

what is the most common STI in the world?

A

HPV

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22
Q

HPV is present in what percent of all cervical cancer?

A

99.7%

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23
Q

Which strains of HPV are high risk?

A

16, 18, 31, 45

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24
Q

Which strains of HPV are low risk?

A

6 and 11

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25
Q

T/F: HPV infects mucosal cells

A

true; CONJUNCTIVAL papilloma, genital and oral papilomas

26
Q

E6/7 are (blank)genes

A

oncogenes

27
Q

How do we Dx HPV?

A

microscopic exam; PCR

28
Q

What are the treatments for HPV?

A

Podophylin, IFN, and cidofovir

29
Q

Liquid nitrogen is used to treat (blank) warts. Surgical removal or use of (blank) acid is also used

A

skin warts; salicylic acid

30
Q

Gardasil vaccine protects against which strains?

A

6, 11, 16, 18

31
Q

Cervarix vaccine protects against which strains?

A

16 and 18 only

32
Q

Even though an HPV infection (warts) may resolve in its own, the viral infection goes (blank)

A

latent

33
Q

What is the topical interferon used to treat HPV genital warts?

A

Imiquimod

34
Q

What is unique about the Parvovirus genome?

A

ssDNA

35
Q

What causes slapped cheek syndrome aka 5th disease? what is the medical name for this disease?

A

Erythema infectiosum; caused by parvovirus

36
Q

What are the other four rashes that gives 5th disease it’s name?

A

Measles, rubella, scarlet fever, and roseola

37
Q

what is the mode of transmission of parvovirus?

A

resp inhalation

38
Q

JC virus and BK virus are two types of (blank) viruses that infect humans

A

polyomavirus

39
Q

T/F: the monkey SV40 polyoma virus can infect humans as well

A

true

40
Q

T/F: polyomavirus genome is only 5kb in size

A

true

41
Q

Progressive multifocal leukoencephalopathy is what?

A

fatal demyelinating disease of white matter involving multiple areas of the brain

42
Q

Progressive multifocal leukoenceophalopathy is seen in what type of infection?

A

polyoma virus

43
Q

What affects the visual field and causes weakness, leading to blindness and dementia and death within six months?

A

PML

44
Q

IN what group of patients do we see PML?

A

AIDS pts

45
Q

(JC/BK) virus can cause nephropathy and graft loss in immune suppresed renal transplant patients

A

BK virus

46
Q

In what percent of people do we find Abs for JC virus?

A

75%

47
Q

T/F: BK virus is also widepsread

A

true

48
Q

When is polyomavirus reactivated?

A

when there is immune compromise

49
Q

Where does polyomavirus persist?

A

Kidney cells, excreted in the urine

50
Q

From what fluid can you do PCR to diagnose polyomavirus?

A

CSF

51
Q

Is there treatment for polyomavirus?

A

nope

52
Q

By what mode of transmission is JCV spread that allows it to reach such high prevalence?

A

respiratory

53
Q

JCV goes latent in kidneys, (blanks and blanks)

A

lungs and lymphoid organs

54
Q

What are the earliest signs of PML?

A

speech and vision abnormalities

55
Q

Kuru is caused by what?

A

prions; eating human brains

56
Q

What are the infectious materials that allow the spread of Creutzfeldt Jacob disease?

A

corneal transplant, brain electrodes, and growth hormone

57
Q

What are the three ways of getting CJD?

A
  1. Iatrogenic infection
  2. Hereditary
  3. Spontaneous mutation
58
Q

prions cause what category of illness?

A

transmissable spongiform encephalitis

59
Q

Scrapie is a (blank) mediated spongiform encephalopathy

A

prion

60
Q

When does CJD normally onset?

A

50-70 years

61
Q

What is the most common cause of CJD?

A

sporadic, over 85%

62
Q

Ingestion of beef infected with BSE prions will lead to what disease?

A

CJD

Block 6 Week 4 Colt (10 decks)

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