(-) RNA Viruses Flashcards

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1
Q

Enveloped paramyxoviridae, helical, H glycoprotein and fusion protein, causes cell to cell fusion and a syncytium of giant cells, live vaccine

A

Measles

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2
Q

Cough, coryza, conjunctivitis with photophobia, red grains on sand on buccal mucosa, maculopapular rash

A

Measles virus

with Koplik spots, can progress to pneumonia with Warthin-Finkeldey cells

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3
Q

Rare late complication of measles virus involving CNS

A

Subacute sclerosing panencephalitis

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4
Q

Helical enveloped paramyxoviridae, HN glycoprotein and F protein, causes lytic infection of epithelial cells of URT and parotid glands that may eventually spread throughout the body, live vaccine

A

Mumps virus

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5
Q

Name the “-itis’s” present in mumps

A

bilateral parotitis (painful), pancreatitis, orchitis (leading to sterility), meningoencephalitis

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6
Q

Helical enveloped paramyxoviridae, causes barking cough in infants

A

Parainfluenza virus (croup)

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7
Q

Helical enveloped paramyxoviridae, causes bronchiolitis and atypical pneumonia in preemies, treat with ribavirin

A

Respiratory Syncytial Virus

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8
Q

Helical enveloped paramyxoviridae, causes 15% of common cold in kids

A

Human metapneumonia virus

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9
Q

Helical enveloped rhabdovirus, binds to peripheral nerves by binding nicotinic ACh receptors or indirectly binds to muscle, causes CNS infection that is rapidly fatal, immunoglobulin and killed vaccine available for post exposure prophylaxis

A

Rabies

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10
Q

Non-specific flu like illness followed by hydrophobia, seizures, disorientation, hallucinatinon, coma, death

A

Rabies

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11
Q

Intracytoplasmic inclusion bodies seen in brain with Rabies infection

A

Negri bodies

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12
Q

Enveloped, helical, filamentous filoviridae, direct contact transmission, causes fatal hemorrhagic fever, calls for Level 4 isolation

A

Ebola and Marburg viruses

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13
Q

Enveloped helical segmented orthomyxoviridae, two envelope glycoproteins H (binds sialic acid and allows entry) and N (binds mucous to allow virus to travel), pathogenesis involving antigenic drift (causing epidemics) and shift (causing pandemic)

A

Influenza virus

A - humans and animals
B - humans only

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14
Q

What type of vaccine is available for Influenza?

A

Killed - incorporated strain, most used in U.S.

Live - intranasal administration

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15
Q

Enveloped bunyavirus, associated with the rainy season and exposure to rodent excrement, causes a pulmonary syndrome with cough, dyspnea, tachycardia, pulmonary effusion, leg aches, and cramps

A

Hantavirus

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16
Q

Pleomorphic enveloped arenaviridae with sandy appearance due to ribosomes in virion

A

Lymphocytic choriomeningitis virus - mice/hamster, influenza like with meningitis

Lassa fever - eating rats in Africa, hemorrhagic fever

17
Q

dsRNA, fecal oral transmission, naked icosahedral, reovirus, causes gastroenteritis in infants with no pus or blood in stool

A

Rotavirus