(-) RNA Viruses Flashcards
Enveloped paramyxoviridae, helical, H glycoprotein and fusion protein, causes cell to cell fusion and a syncytium of giant cells, live vaccine
Measles
Cough, coryza, conjunctivitis with photophobia, red grains on sand on buccal mucosa, maculopapular rash
Measles virus
with Koplik spots, can progress to pneumonia with Warthin-Finkeldey cells
Rare late complication of measles virus involving CNS
Subacute sclerosing panencephalitis
Helical enveloped paramyxoviridae, HN glycoprotein and F protein, causes lytic infection of epithelial cells of URT and parotid glands that may eventually spread throughout the body, live vaccine
Mumps virus
Name the “-itis’s” present in mumps
bilateral parotitis (painful), pancreatitis, orchitis (leading to sterility), meningoencephalitis
Helical enveloped paramyxoviridae, causes barking cough in infants
Parainfluenza virus (croup)
Helical enveloped paramyxoviridae, causes bronchiolitis and atypical pneumonia in preemies, treat with ribavirin
Respiratory Syncytial Virus
Helical enveloped paramyxoviridae, causes 15% of common cold in kids
Human metapneumonia virus
Helical enveloped rhabdovirus, binds to peripheral nerves by binding nicotinic ACh receptors or indirectly binds to muscle, causes CNS infection that is rapidly fatal, immunoglobulin and killed vaccine available for post exposure prophylaxis
Rabies
Non-specific flu like illness followed by hydrophobia, seizures, disorientation, hallucinatinon, coma, death
Rabies
Intracytoplasmic inclusion bodies seen in brain with Rabies infection
Negri bodies
Enveloped, helical, filamentous filoviridae, direct contact transmission, causes fatal hemorrhagic fever, calls for Level 4 isolation
Ebola and Marburg viruses
Enveloped helical segmented orthomyxoviridae, two envelope glycoproteins H (binds sialic acid and allows entry) and N (binds mucous to allow virus to travel), pathogenesis involving antigenic drift (causing epidemics) and shift (causing pandemic)
Influenza virus
A - humans and animals
B - humans only
What type of vaccine is available for Influenza?
Killed - incorporated strain, most used in U.S.
Live - intranasal administration
Enveloped bunyavirus, associated with the rainy season and exposure to rodent excrement, causes a pulmonary syndrome with cough, dyspnea, tachycardia, pulmonary effusion, leg aches, and cramps
Hantavirus