(-) RNA Viruses

Question 1

Enveloped paramyxoviridae, helical, H glycoprotein and fusion protein, causes cell to cell fusion and a syncytium of giant cells, live vaccine

Answer 1

Measles

Question 2

Cough, coryza, conjunctivitis with photophobia, red grains on sand on buccal mucosa, maculopapular rash

Answer 2

Measles virus

with Koplik spots, can progress to pneumonia with Warthin-Finkeldey cells

Question 3

Rare late complication of measles virus involving CNS

Answer 3

Subacute sclerosing panencephalitis

Question 4

Helical enveloped paramyxoviridae, HN glycoprotein and F protein, causes lytic infection of epithelial cells of URT and parotid glands that may eventually spread throughout the body, live vaccine

Answer 4

Mumps virus

Question 5

Name the “-itis’s” present in mumps

Answer 5

bilateral parotitis (painful), pancreatitis, orchitis (leading to sterility), meningoencephalitis

Question 6

Helical enveloped paramyxoviridae, causes barking cough in infants

Answer 6

Parainfluenza virus (croup)

Question 7

Helical enveloped paramyxoviridae, causes bronchiolitis and atypical pneumonia in preemies, treat with ribavirin

Answer 7

Respiratory Syncytial Virus

Question 8

Helical enveloped paramyxoviridae, causes 15% of common cold in kids

Answer 8

Human metapneumonia virus

Question 9

Helical enveloped rhabdovirus, binds to peripheral nerves by binding nicotinic ACh receptors or indirectly binds to muscle, causes CNS infection that is rapidly fatal, immunoglobulin and killed vaccine available for post exposure prophylaxis

Answer 9

Rabies

Question 10

Non-specific flu like illness followed by hydrophobia, seizures, disorientation, hallucinatinon, coma, death

Answer 10

Rabies

Question 11

Intracytoplasmic inclusion bodies seen in brain with Rabies infection

Answer 11

Negri bodies

Question 12

Enveloped, helical, filamentous filoviridae, direct contact transmission, causes fatal hemorrhagic fever, calls for Level 4 isolation

Answer 12

Ebola and Marburg viruses

Question 13

Enveloped helical segmented orthomyxoviridae, two envelope glycoproteins H (binds sialic acid and allows entry) and N (binds mucous to allow virus to travel), pathogenesis involving antigenic drift (causing epidemics) and shift (causing pandemic)

Answer 13

Influenza virus

A - humans and animals
B - humans only

Question 14

What type of vaccine is available for Influenza?

Answer 14

Killed - incorporated strain, most used in U.S.

Live - intranasal administration

Question 15

Enveloped bunyavirus, associated with the rainy season and exposure to rodent excrement, causes a pulmonary syndrome with cough, dyspnea, tachycardia, pulmonary effusion, leg aches, and cramps

Answer 15

Hantavirus

Question 16

Pleomorphic enveloped arenaviridae with sandy appearance due to ribosomes in virion

Answer 16

Lymphocytic choriomeningitis virus - mice/hamster, influenza like with meningitis

Lassa fever - eating rats in Africa, hemorrhagic fever

Question 17

dsRNA, fecal oral transmission, naked icosahedral, reovirus, causes gastroenteritis in infants with no pus or blood in stool

Answer 17

Rotavirus