Rickettsia And Chlamydia Flashcards

1
Q

Where do rickettsia and chlamydia live in the body?

A

Obligate intracellular

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2
Q

Shape of rickettsia and chlamydia

A

Gram neg

Coccobacilli

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3
Q

____________ are arthropod transmitted parasites of blood cells or endothelial cells, while _______________ are direct transmission of epithelial cells

A

Rickettsia; chlamydia

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4
Q

How are rickettsia and chlamydia infections diagnosed?

A

Direct stain (Buffy coat)
PCR
Serology
Cell culture

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5
Q

What antimicrobial are rickettsia and chlamydia susceptible to?

A

Tetracycline

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6
Q

What are the reservoirs of rickettsia?

A

Small mammals and rodents

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7
Q

What disease can rickettsia rickettsia cause in humans and dogs

A

Rocky Mountain spotted fever

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8
Q

Where does rickettsia rickettsia replicate?

A

Endothelial cells of sm blood vessels

-> cause platelet activation, coagulation, and necrotizing vasculitis

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9
Q

Fever, depression, anorexia, SQ edema, petechia of mucosa , and stiff gait in a dog

A

Rocky Mountain spotted fever

-> rickettsia rickettsia

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10
Q

____________ causes flea-borne spotted fever in humans, but is in apparent in cats.

A

Rickettsia felis

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11
Q

How is rickettsia felis transmitted

A

Cat flea

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12
Q

What rickettsia bacteria belong to the typhus group?

A

Rickettsia prowazekii
Rickettsia typhi
Orientia tustasugamushi

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13
Q

Host of rickettsia prowazekii

A

All domestic animals
Human
Squirrel

Louse borne

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14
Q

Host of rickettsia typhi?

A

Murine typhus

Opossum/flea cycle

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15
Q

_________________ causes scrub typhus and is carried to chigger mites on birds in rodents

A

Orientia tustusgamushi

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16
Q

What are treatment methods of rickettsia infection

A

Tetracycline
Doxycycline
Chloramphenicol
Enrofloxacin

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17
Q

______________ is found in farmed fish causing major economic loss.

A

Piscrickettsia salmonis

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18
Q

Anaplasmataceae are parasites of _________________ within vertebrate hosts

A

Hematopoietic (bone marrow deceived cells)

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19
Q

How are anaplasmataceae transmitted?

A

On invertebrae host or vector (tick)

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20
Q

What species belong to the Anaplasmataceae family?

A

Anaplasmataceae
Eherlicia
Neorickettsia

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21
Q

Anaplasmataceae phagoyctophilium are found where in the host

A

Neutrophils

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22
Q

What transmits Anaplasma phagocytophilum?

A

Ixodes ticks

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23
Q

Fever, depression, neutropenia, thrombocytopenia, muscle pain in small animals

A

Anaplasma phagycytophilum

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24
Q

Mild limb edema, icterus, ataxia, DIC in horse

A

Anaplasma phagocytophilum

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25
What does Anaplasma phagocytophilum cause in dog
Necrotizing small vessel vasculitis
26
How do we control Anaplasma phagycophilum
Tick control
27
How do we diagnose Anaplasma phagocytophilum
Direct stain- Buffy coat PCR SNAP test
28
Anaplasma platys infects what cells?
Platelets | Infectious cyclic thrombocytopenia
29
How do we diagnose Anaplasma platys
Blood smear -> seen in thrombocytes /platelets FA -can be false negative if not done at right stage of disease PCR
30
Dog with fever, uveitis, petechial, and ecchymosis on St. Kitts
Anaplasma platys
31
What is the principal cell target of Anaplasma marginale?
Erythrocytes
32
Host of Anaplasma marginale?
Ruminants
33
Transmission of Anaplasma marginales
Tick/flies | Blood contaminated fomites
34
T/F: calves are much more resistant to disease by Anaplasma marginale than older cattle
T
35
Ruminant South eastern US Fever, anemia, jaundice/icterus
Anaplasma marginale
36
What are the causative agents of tick fever in cattle?
Anaplasma marginale Babesia bigemina Babesia bovis
37
You do a necropsy and find splenomegaly in ruminant? What are your thoughts?
Anaplasma marginale Not in an endemic area? Anthrax :O Why the F are you opening up an anthrax cattle?!
38
Diagnosis of Anaplasma marginale
``` Direct stain FA PCR ELISA CARD test ```
39
Control of Anaplasma marginale?
Tick control | Treatment of carrier cattle with long acting tetracycline
40
What causes tropical pancytopenia in dogs?
Ehrlichia canis
41
How is Ehlichia transmitted?
Brown dog tick
42
What disease do the doggos get from Eherlichia?
Mononuclear and endothelial cell infection Multi-systemic disease (acute) -> pahncytopenia (chronic) Hemorrhage
43
Dog Weight loss, bleeding, vasculitis, epistaxis, secondary infections
canine ehrlichiosis
44
Etiology of heart water disease
Ehrlichia ruminatium
45
Where do you find Ehrlichia ruminantium
Africa | Caribbean
46
What do you do if you find Eherlichia ruminantium in the US (or Canada )
Report. Why do you come here?!!??!?
47
What cells does Eherlichia ruminatium replicate in?
Machrophage and endothelial cells
48
Vector of E. ruminantium?
Ambyloma Those dang ticks
49
Who does E. ruminantium infect
The ruminants.. Moo Baaa + goat Antelope
50
What signs will you see in E. ruminatium?
Respiratory and neurological signs
51
Best way to diagnose E. ruminantium?
PCR
52
How do you control your E. ruminantium?
Chemoprophylaxis
53
Is neorickettsia an intracellular or extracellular bacteria
Intracellular... we already been through this.. the rickettsia are intracellular ..
54
Who transmits neorickettsia ?
Trematode (flukes) Remember that one time in parasite class?
55
Neorickettsia live in the __________ cells
Macrophage
56
What causes Potomac horse fever?
Neorickettsia risticii
57
Throw back to that time we learned about trematode life cycle... who is the intermediate host?
Snails---> horse drunk them infected waters
58
Neorickettsia helminthoeca causes ______________ in the ____________________
Salmon poisoning; polar bears (also other animals of the Pacific Northwest... like doggos)
59
You are up in the great country of Canada.. lets say Vancouver... Doggo has... Fever, depression, dehydration, anorexia, vomiting, hemorrhagic diarrhea, and lymphadenopathy
Neorickettsia helminthoeca Ugh.. its like they want us to remember all the parasite things..
60
How would you diagnose your doggo with neorickettsia ?
Fluke eggs (should your float or sink?) History Geographical location
61
T/ F: neorickettsia risticii is seasonal
T | June to October
62
Horse with fever, anorexia, leukopenia, severe diarrhea, laminitis
Neorickettsia risticii
63
How do you treat your neorickettsia infections?
Tetracycline
64
T/F: vaccines are successful at controlling neorickettsia risticii?
Nope Antigenic variation limits the value of available vaccines
65
Doggo Fever, depression, dehydration, anorexia, vomiting, hemorrhagic diarrhea, and lymphadenopathy
Neorickettsia helminthoeca
66
How do you treat your neorickettsia helminthoeca in your doggos
Tetracycline for the bacteria | Praziquantel for the tremetode
67
T/F: chlamydia is an facultative intracellular bacteria
False Obligate intracelllar
68
Chlamydia infects what cells?
Epithelial cells
69
What are the unique features of chlamydia
Dimorphism life cycle ->Intracellular replicating form (reticulate body) ->Extracellular non-replicating form (elementary body) Energy parasites (do not generate ATP)
70
______________ are the infectious stage of chlamydia and can survive outside the host
Elementary bodies
71
What are disease caused by chlamydia
Enteritis, abortion, polyarthritis, polyserositis, conjunctivitis, and pneumonia
72
What chlamydia sp is zoonotic?
C.psittaci Also REPORTABLE.
73
Chlamydia psittaci causes what disease?
Avian chlamydiosis, ornithosis, or psittacosis Zoonotic and Reportable !!! BSL3
74
How do you diagnose a psittacosis infection
Giemsa stain, FA, and PCR Isolation Serology
75
How should pisttacosis be controlled?
REPORT Isolation and quarantine procedures imported birds No vaccine :(
76
Chlamydia pecorum infects what hosts? What do we call the disease?
Lambs and calves Stiff lamb disease / sporadic bovine encephalomyelitis (SBE)
77
What does chlamydia pecorum cause in ruminants?
Polyarthritis | Locomotor, postural behavioral disturbances
78
What is the known agent causing feline penumonitis?
Chlamydia felis
79
What are the most common signs of chlamydia felis?
Conjunctivitis and rhinitis
80
Who is host to chlamydia felis
Endemic in housecats worldwide -> low zoonotic risk Asympotmatic carriers and shedding from repro tract
81
How do you diagnose a chlamydia infeciton?
Cytology - special stains, FA for inclusion bodies Culture - embryonated egg, tissue culture, animal inoculation Serology PCR
82
How do you treat chlamydia infection?
Tetracycline Drugs that affect protein or nucleic acid synthesis - chloramphenicol - macrolide - fluoroquinolones - rifampin
83
What causes Q (Queensland) fever?
Coxiella burnetii
84
Who is infected by coxiella burnetii?
Broad host range Cattle, sheep, and goat More uncommon - cats and rabbit ZOONOTIC
85
T/F: coxiella burnetii is highly persistent in the environment
T Has endosperm-like form
86
T/F: chlamydia pecorum is a bioterrorist agent
False Coxiella burnetii is a bioterroist agent
87
Coxiella burnetii causes ________________ and __________ in sheep and goats
Placentitis and abortion
88
How do you diagnose coxiella infection
Serology Culture PCR
89
Treatment of coxiella?
Tetracycline | Fluoroquinolones
90
Control of coxiella?
Hygiene Education Early diagnosis Vaccinate humans and animals at risk