ribosome genesis

Question 1

What are ribosomal DNA (rDNA) and their function?

Answer 1

Genes that code for ribosomes

• rDNA is crucial for the synthesis of ribosomal RNA (rRNA), which forms the structural and functional components of ribosomes.
• located in muscles

Question 2

Which transcription factors initiate the transcription of rRNA from rDNA?

Answer 2

c-Myc

c-Myc is a key regulator that activates the transcription of ribosomal RNA needed for ribosome formation.

Question 3

What is pre-rRNA?

Answer 3

The initial immature RNA molecule transcribed from rDNA

Pre-rRNA must undergo processing to become mature rRNA subunits.

Question 4

What are the mature rRNA subunits produced from pre-rRNA processing?

Answer 4

• 28S
• 5.8S
• 18S

These subunits are essential components of the ribosomes.

Question 5

What happens to mature rRNA molecules after they are formed?

Answer 5

They associate with ribosomal proteins to form 60S and 40S ribosomal subunits

This assembly is crucial for the formation of functional ribosomes.

Question 6

Where are the ribosomal subunits transported after formation?

Answer 6

Into the cytoplasm

This transport is necessary for ribosome assembly and subsequent protein synthesis.

Question 7

What is the result of combining 40S and 60S subunits?

Answer 7

Functional, mature ribosomes

These ribosomes serve as the protein synthesis machinery of the cell.