NSAIDs Flashcards
What are NSAIDs?
NSAIDs are over-the-counter (OTC) medications used to reduce pain and inflammation. Common examples include ibuprofen, naproxen, and aspirin.
Typical dosages and daily limits vary; for ibuprofen, the daily limit is often cited as 1200 mg.
How do NSAIDs work?
NSAIDs function as cox-enzyme inhibitors, blocking the synthesis of prostaglandins that contribute to pain and inflammation.
Exercise increases prostaglandin synthesis, and NSAIDs can attenuate this increase.
What is the acute effect of NSAIDs on muscle adaptations?
Acute NSAID supplementation after eccentric exercise decreases satellite cell number and muscle protein synthesis.
Studies using ibuprofen at 1200 mg or local infusion of indomethacin demonstrated this.
What are the chronic effects of NSAIDs on muscle hypertrophy in young adults?
Evidence regarding chronic effects is mixed; lower doses show little to no effect, while high doses may attenuate hypertrophy.
A recent study suggests limited effect of OTC ibuprofen on muscle hypertrophy mechanisms during resistance training.
What are the chronic effects of NSAIDs on muscle hypertrophy in older adults?
Some evidence suggests increased hypertrophy with high doses of NSAIDs, but most studies show no effect on hypertrophy.
This may be due to counteracting heightened baseline inflammation.
What do studies indicate about NSAIDs and muscle strength in young adults?
Studies show no significant differences in strength with equal workloads; however, high doses may attenuate strength and performance.
One study found no strength differences after six weeks with 400 mg of ibuprofen.
What does research suggest about NSAIDs and muscle strength in older adults?
A meta-analysis indicated a small positive effect of NSAID supplementation on strength, but it was not statistically significant.
Other studies found no significant differences in strength adaptations.
What is the recommended effective dosage of ibuprofen for influencing muscle metabolism?
An effective dosage of 1200 mg of ibuprofen is required to influence skeletal muscle metabolism and resistance training adaptations.
Chronic NSAID consumption carries risks, especially to GI, renal, and cardiovascular systems.
What are the safety risks of chronic NSAID consumption?
Chronic NSAID consumption carries risks to the gastrointestinal, renal, and cardiovascular systems, especially in older adults.
Factors like medicine interactions and pre-existing conditions increase these risks.
What is the recommendation for NSAID use during exercise in young adults?
Daily or occasional low doses of OTC NSAIDs are unlikely to have detrimental effects on resistance training adaptations.
There are no additional benefits to taking NSAIDs to enhance resistance training adaptations.
What is the recommendation for NSAID use during exercise in older adults?
NSAIDs are not recommended to enhance resistance training adaptations, but they may be used for joint pain or inflammation.
High doses in some cases may enhance resistance training adaptations.
Is it recommended to take NSAIDs solely for resistance training adaptations?
No, it is not recommended to take NSAIDs solely for this purpose due to risks of adverse drug reactions.
Consult with a physician before taking them regularly.
What research gaps exist regarding NSAIDs and resistance training?
There is a lack of direct comparisons between young and older participants in studies, and more research is needed on chronic disease populations.
Future studies should also investigate other NSAIDs besides ibuprofen.
