rheumatology formative

Question 1

SLE antibody

Answer 1

Anti-dsDNA

Question 2

What is the treatment for connective tissue disorders ie ehlers danlos

Answer 2

Treat symptomatically and monitor for major complications

Question 3

SLE treatment

Answer 3

Hydroxychloroquine

Question 4

What would NOT be a likely cause of chest pain in a patient with SLE

Answer 4

Pneumothorax

• could get MI, pleurisy, pericarditis, pul. Embolus

Question 5

What sex does SLE affect more commonly

Answer 5

Female 9:1

Question 6

Features of anti-phospholipid syndrome

Answer 6

Recurrent pregnancy loss
Venous thrombosis
Livedo reticularis
Migraine

Question 7

1st line investigation for suspected SLE

Answer 7

Urinalysis > renal biopsy if blood / protein

Question 8

A patient is diagnosed in the respiratory clinic as having pulmonary fibrosis. The chest physician notes that she has Raynaud’s phenomenon, dry eyes, facial telangiectasia and puffy hands. What is the most likely diagnosis

Answer 8

DIFFUSE systemic sclerosis

(Internal organ involvement !!!)

Question 9

What are the nail changes associated with psoriatic arthritis ?

Answer 9

Onycholysis

Pitting

Question 10

What are the spondyloarthropathies

Answer 10

AS
Psoriatic arthritis
Reactive arthritis

Question 11

What medical conditions is sacroilitis associated with other than AS

Answer 11

Crohns (20%)

Question 12

RF is positive at what percent for people with RA

Answer 12

85%

Question 13

What are second line fro RA

Answer 13

Anti-TNF + anti-IL6

Question 14

What is 3rd line for RA

Answer 14

Azathioprine

Question 15

Is allopurinol a drug that can be used in the acute management of gout

Answer 15

No it is a prophylactic drug

Corticosteroids, colchicine is for acute gout attack

Question 16

Initial investigator fro Polymyalgia rheumatica

Answer 16

ESR

Question 17

antibody associate with polymyositis

Answer 17

Anti-Jo-1

Question 18

Antibody associated with primary biliary cirrhosis

Answer 18

Anti-mitochondrial

Question 19

Features of DMARDS

Answer 19

• reduce rate of progression of joint damage
• require regular BP monitoring
• slow acting
• should aim to be used within 12 weeks of symptoms presenting in patients
• patients will still need painkillers on top of DMARDS

Question 20

What are the large vessel arteritides

Answer 20

GCA and Takayasu

Question 21

What are the medium vessel vasculitides

Answer 21

Polyarteritis nodosa
Kawasakis

Question 22

What are the small vessel vasculitides

Answer 22

GPA / wegeners
eGPA / churg Strauss
Microscopic polyangiits

Question 23

What vasculitides are generally ANCA negative

Answer 23

Large adn medium

Question 24

What vasculitis is positive for ANCA

Answer 24

Small vessel vasculitides

Question 25

Associated disease of anti-PR3

Answer 25

GPA

Question 26

Associated disease of anti-MPO ANCA

Answer 26

Eosinophilic GPA

Question 27

Can you give live vaccinations when on DMARDS

Answer 27

NO - should be given prior

Question 28

Which drugs for rheumatological treatments should be stopped in pregnancy

Answer 28

NSAIDs
Methotrexate

Question 29

If a women with RA on methotrexate wants to start a family when should she stop taking her DMARD

Answer 29

3 months before conception

Question 30

Polymyalgia rheumatica vs polymyositis

Answer 30

PR = pain and stiffness

Poly = WEAKNESS