daily mix I Flashcards
In terms of urine output what constitutes an AKI
Urine output of <0.5 ml/kg/hr over 6 consecutive hours
What constitutes an AKI (3 things)
-rise in serum creatinine of 26 micromol/litre or greater within 48 hours
-50% or greater rise in serum creatinine known or presumed to have occurring within the past 7 days
-fall in urine output less than 0.5ml/if/gout more than 6 hours in adults
why does CKD commonly cause anaemia
Loss of kidney’s production of erythropoietin
Also poor iron absorption
Treatment of anaemia in CKD
1st = start oral iron replacement
Which disease gives a hyperchloremic metabolic acidosis ?
Renal tubular acidosis
what is the first-line screening test for adult poly cystic kidney disease
Renal ultrasounds
What can cause contrast-induced nephropathy ?
Iodine based CT and X-ray
What should be given to counter contrast-induced nephropathy ?
Volume expansion via 1L IV 0.9% sodium chloride
What is the most common extra-renal manifestation of ADPKD
Liver cysts
what causes subarachnoid haemorrhage in ADPKD
Pancreatic cyst and berry aneurysms (much less common than liver cysts)
Treatment of Minimal change glomerulonephritis
Prednisolone (steroids + ACEi)
When does Alports usually present ?
Childhood
Features seen in Alports
Microscopic haematuria
Progressive renal failure
Bilateral sensorineural deafness
Lenticonus
Retinitis pigmentosa
Splitting of lamina densa on electron microscopy
Presents at childhood
Investigation of Alports
Genetic testing
Renal biopsy
What is seen on renal biopsy for Alports
Splitting of the Lamina densa of the GBM - resulting in a basket weave appearance
*basket weave appearance on renal biopsy
Alports
what to do if a patient has < 0.5ml/kg/hr urine output post-operatively ?
Administer 500ml 0.9% sodium chloride over 15 minutes
What is the most likely cause of death in someone with CKD on HD
Ischaemic heart disease
What is acral lentiginous melanoma
Pigmentation of nail bed affecting proximal nail fold = melanoma
- red or black lump / lump that bleeds or oozes
Nodular Malignant melanoma
What type of lesion is most commonly seen with renal transplantation
Squamous cell carcinoma
What drug can cause patchy depigmentation in patients with darker skin
Topical steroids (ie clobetasone)
Steroid cream potency (eczema)
Where are keloid scars most commonly found
Sternum
What is used to treat dermatophyte infection
Oral terbafine
What fungus is responsible for pityriasis versicolor
Malassezia furfur
*central dimple, 2mm in diameter, multiple raised lesions
Molluscum contagiosum
What medication can cause toxic epidermal necrolysis
Penicillins ie co-amoxiclav
What is nikolsky’s sign
Epidermis separates with mild lateral pressure
Skin lesion associated with UC
Pyoderma gangrenosum
Most common cause of cauda equina syndrome
Central disc prolapse at L4/5 or L5/S1
Investigation for suspected cauda equina syndrome
Urgent MRI
Management of Cauda equina syndrome
Urgent decompression
Late sign of cauda equina syndrome
Urinary incontinence
What do the Ottawa rules apply to ?
When to use an X-ray for ankle / knee injury
MAIN ASSOCIATION for adhesive capsulitis
Diabetes !!
Dermatomyositis associated antibody
Anti-Jo-I and ANA
what needs to be done after confirmed diagnosis of Dermatomyositis
Screen for underlying malignancy ie breast or lung (typically)
Main side effect of hydroxychloroquine
Bull’s eye retinopathy
*BULLS EYE RETINOPATHY
Hydroxychloroquine use
What do you have to check in a patient before commencing them on azathioprine
Thiopurine methyltransferase deficiency
If they have a deficiency then they are predisposed to azathioprine toxicity
S1 compression symptoms
Sensory loss in posterolateral aspect of leg
Lateral aspect of foot
Weakness in the plantar flexion of the foot
What does S1 innervate
Gastrocnemius and soleus = responsible for plantar flexion
L3 compression symptoms
Sensory loss over anterior thigh
Weak hip flexion (iliopsoas)
Knee extension (quadriceps)
Hip adduction (Adductor)
Reduced knee reflex