Rheumatology Flashcards
acute rheumatic fever - major criteria
SPACE: subcutaneous nodules pancarditis arthritis (migratory) chorea erythema marginatum
acute rheumatic fever - minor criteria
fever, arthralgia, increased ESR/CRP, prolonged PR
diagnosis of acute rheumatic fever
2 major criteria OR 1 major and 2 minor + evidence of GAS infection
tx of rheumatic fever
penicillin x 10 days, prophy penicillin x 5 yrs or until age 21 (lifelong if carditis present)
ASA for arthritis, carditis
what HLA is associated with rheumatologic conditions?
HLA B27 (class I gene) is associated with spondylarthritis and enthesistis related JIA
definition of oligo JIA
max 4 involved joints in 6 months
what is associated with oligoarticular JIA?
uveitis (associated with positive ANA, cause of blindness!)
what is a secondary complication of systemic JIA
MAS
definition of systemic JIA
> 2 weeks of fever, arthritis AND one of:
- rash
- lymphadenopathy
- hepatosplenomegaly
- serositis
biologics used in systemic JIA
anti-IL1 (anakinra), anti-IL6 (tocilizumab)
gene associated with FMF
MEFV, production of pyrin (regulates neutrophil-mediated inflammation)
features of FMF
brief, recurrent episodes (1-3 days) of fever, assoc with painful polyserositis (peritonitis, pleuritis, arthritis)
what is the risk of untreated FMF
amyloidosis in 60%, renal failure
PFAPA
regularly recurring fevers with apthous stomatitis, cervical lymphadenopathy, pharyngitis (in the absence of URTI sxs)
what is the most common vital organ involved in SLE?
kidney (glomerulonephritis)
