Rheumatology Flashcards
acute rheumatic fever - major criteria
SPACE: subcutaneous nodules pancarditis arthritis (migratory) chorea erythema marginatum
acute rheumatic fever - minor criteria
fever, arthralgia, increased ESR/CRP, prolonged PR
diagnosis of acute rheumatic fever
2 major criteria OR 1 major and 2 minor + evidence of GAS infection
tx of rheumatic fever
penicillin x 10 days, prophy penicillin x 5 yrs or until age 21 (lifelong if carditis present)
ASA for arthritis, carditis
what HLA is associated with rheumatologic conditions?
HLA B27 (class I gene) is associated with spondylarthritis and enthesistis related JIA
definition of oligo JIA
max 4 involved joints in 6 months
what is associated with oligoarticular JIA?
uveitis (associated with positive ANA, cause of blindness!)
what is a secondary complication of systemic JIA
MAS
definition of systemic JIA
> 2 weeks of fever, arthritis AND one of:
- rash
- lymphadenopathy
- hepatosplenomegaly
- serositis
biologics used in systemic JIA
anti-IL1 (anakinra), anti-IL6 (tocilizumab)
gene associated with FMF
MEFV, production of pyrin (regulates neutrophil-mediated inflammation)
features of FMF
brief, recurrent episodes (1-3 days) of fever, assoc with painful polyserositis (peritonitis, pleuritis, arthritis)
what is the risk of untreated FMF
amyloidosis in 60%, renal failure
PFAPA
regularly recurring fevers with apthous stomatitis, cervical lymphadenopathy, pharyngitis (in the absence of URTI sxs)
what is the most common vital organ involved in SLE?
kidney (glomerulonephritis)
most sensitive test for lupus
ANA
HSP
palpable purpura, arthritis, abdo pain, IgA nephropathy
tx kawasaki
IVIG 2 g/kg
