Allergy Flashcards
Disadvantage of serum specific IgE
High rate of false positives if elevated total IgE (non-specific binding)
What type of test is the serum specific IgE
ELISA
How many kids will outgrow a milk or egg allergy
80-90%
Percent of kids that will outgrow peanut allergy
20%
what infants are at high risk of developing food allergy?
those with a first degree relative with an allergic condition
what conditions (4) can be managed with immunotherapy
venom allergy, allergic rhinitis, allergic asthma, atopic dermatitis
penicillin anaphylaxis is mediated by….
IgE against a major determinant (only 10% a reaction to minor determinant)
percent of body surface area involved in toxic epidermal necrolysis
> 30%
percent of body surface area involved in steven johnsons syndrome
<10%
do you give the inactivated influenza vaccine in a kid with egg allergy?
YES, as single dose
definition of urticaria
elevated pruritic lesion lasting < 24 hrs
if a hive stays in same position > 48 hrs, what should you think of?
urticarial vasculitis, autoimmune condition
definition of chronic urticaria
lasts > 6 weeks
how do you manage urticaria
standard dose of 2nd generation non-sedating antihistamine
what do you do if urticaria doesn’t respond to standard dose of second generation non-sedating antihistamine, and symptoms persist x 2 weeks?
increase dose of antihistamine x 4
how is hereditary angioedema inherited?
autosomal dominant
what causes hereditary angioedema
hereditary C1 esterase inhibitor deficiency
how do you treat hereditary angioedema
replacement of C1 inhibitor (blood product)
What is the C4 level in hereditary angioedema
decreased in type 1/2
what is pollen food allergy syndrome
IgE mediated reaction caused by allergens in plants, to foods that are cross-reactive (ie. birch and peach/apple)
can you have a systemic allergic reaction in pollen food allergy syndrome?
yes, up to 10% of patients will have this
